{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,14]],"date-time":"2026-11-14T04:15:52Z","timestamp":1794629752053,"version":"4.9.1"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,11,21]],"date-time":"2007-11-21T00:00:00Z","timestamp":1195603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Mandibular repositioning appliances (MRAs) reduce symptoms of obstructive sleep apnoea in the short term, but the long\u2010term effects are unknown. Our objective was to evaluate the long\u2010term symptomatic effects of custom\u2010made MRAs and to identify the patients who will experience subjective benefits from treatment. A cohort of 260 consecutive patients treated with appliances for non\u2010apnoeic snoring or sleep apnoea was followed up by a questionnaire and examination after an average of 5.4\u2003years. The subjective effect was defined as good when complaints of daytime sleepiness occurred less than once a week. A total of 185 patients (71%) responded to the questionnaires. Of the respondents, 96 reported frequent use, 33 reported infrequent use, 26 reported discontinued treatment and 30 reported modified treatment. Mild cases (apnoea\u2013hypopnoea index [AHI]\u2003&lt;\u200315) were likelier than more severe cases to continue treatment. Patients who had used MRAs reported fewer complaints of sleepiness, headaches and daytime naps. Frequent use (<jats:italic>P<\/jats:italic>\u2003=\u20030.001), few night\u2010time awakenings before start of treatment (<jats:italic>P<\/jats:italic>\u2003=\u20030.02) and effective apnoea reduction during treatment of more severe cases (<jats:italic>P<\/jats:italic>\u2003=\u20030.02) correlated with a good subjective effect at long\u2010term follow\u2010up. Our conclusion is that custom\u2010made MRAs reduce sleep apnoea symptoms in the long term. The mildest cases will experience the greatest long\u2010term benefit. The reason is that non\u2010apnoeic snorers and patients with a mild disease are more likely to continue treatment and that their long\u2010term results with regard to excessive sleepiness are similar to patients with a more severe disease.<\/jats:p>","DOI":"10.1111\/j.1365-2869.2007.00615.x","type":"journal-article","created":{"date-parts":[[2007,11,21]],"date-time":"2007-11-21T12:40:19Z","timestamp":1195648819000},"page":"414-420","source":"Crossref","is-referenced-by-count":45,"title":["Long\u2010term effects of mandibular repositioning appliances on symptoms of sleep apnoea"],"prefix":"10.1111","volume":"16","author":[{"given":"MARIE","family":"MARKLUND","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KARL A.","family":"FRANKLIN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,11,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2005.00372.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2005.04.034"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/22.5.667"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200311-1571OC"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-005-0003-4"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/22.1.53"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2003.015867"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/29.2.244"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-003-0131-7"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200203-208OC"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/B0-72-160797-7\/50094-X"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-5406(97)70293-2"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/29.2.240"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/B0-72-160797-7\/50113-0"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004435.pub3"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2005.10.004"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.125.4.1270"},{"key":"e_1_2_7_19_1","doi-asserted-by":"crossref","first-page":"374","DOI":"10.5664\/jcsm.26365","article-title":"Effect of oral appliance therapy on neurobehavioural functioning in obstructive sleep apnoea: a randomized controlled trial","volume":"1","author":"Naismith S. L.","year":"2005","journal-title":"J. Clin. Sleep Med."},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2004.00897.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2869.1995.tb00205.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/B0-72-160797-7\/50099-9"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016350310007130"},{"issue":"1","key":"e_1_2_7_24_1","first-page":"9","article-title":"The International Classification of Headache Disorders: 2nd edition","volume":"24","author":"International Headache Society","year":"2004","journal-title":"Cephalalgia"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpr.2002.123228"}],"container-title":["Journal of Sleep Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2869.2007.00615.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2869.2007.00615.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T01:06:40Z","timestamp":1697245600000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2869.2007.00615.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11,21]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["10.1111\/j.1365-2869.2007.00615.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2869.2007.00615.x","archive":["Portico"],"relation":{},"ISSN":["0962-1105","1365-2869"],"issn-type":[{"value":"0962-1105","type":"print"},{"value":"1365-2869","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,11,21]]}}}