{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T03:26:56Z","timestamp":1770434816945,"version":"3.49.0"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,6,28]],"date-time":"2008-06-28T00:00:00Z","timestamp":1214611200000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The aim of this trial was to evaluate the efficacy of a mandibular advancement appliance (MAA) for obstructive sleep apnoea (OSA). Ninety\u2010three patients with OSA and a mean apnoea\u2013hypopnoea index (AHI) of 34.7 were centrally randomised into three, parallel groups: (a) MAA; (b) mandibular non\u2010advancement appliance (MNA); and (c) no intervention. The appliances were custom made, in one piece. The MAAs had a mean protrusion of the mandible of 74% (range 64\u201385%). Outcome measures, assessed after continuous use for 4\u2003weeks, were AHI (polysomnography), daytime sleepiness (Epworth) and quality of life (SF\u201036). Eighty\u2010one patients (87%) completed the trial. The MAA group achieved mean AHI and Epworth scores significantly lower (<jats:italic>P\u2003<\/jats:italic>&lt;<jats:italic>\u2003<\/jats:italic>0.001 and <jats:italic>P\u2003<\/jats:italic>&lt;<jats:italic>\u2003<\/jats:italic>0.05) than the MNA group and the no\u2010intervention group. No significant differences were found between the MNA group and the no\u2010intervention group. The MAA group had a mean AHI reduction of 14.1 (95% CI 7.4\u201320.8), and a mean Epworth score reduction of 3.3 (95% CI 1.8\u20134.8). Eight MAA patients (30%) achieved a reduction in AHI \u226575% ending with an AHI &lt;5, half of them having baseline AHI &gt;30. Sensitivity analyses confirmed these results. MAA had a significant beneficial effect on the vitality domain of SF\u201036. Four MAA patients (14.8%) and two MNA patients (8%) discontinued interventions because of adverse effects. Our conclusion is that MAA has significant beneficial effects on OSA, including cure in some cases of severe OSA. Protrusion of the mandible is essential for the effect. MNA has no placebo effect. MAA may be a good alternative to CPAP in subsets of OSA patients.<\/jats:p>","DOI":"10.1111\/j.1365-2869.2008.00645.x","type":"journal-article","created":{"date-parts":[[2008,5,13]],"date-time":"2008-05-13T10:31:17Z","timestamp":1210674677000},"page":"221-229","source":"Crossref","is-referenced-by-count":125,"title":["Mandibular advancement appliance for obstructive sleep apnoea: results of a randomised placebo controlled trial using parallel group design"],"prefix":"10.1111","volume":"17","author":[{"given":"NIELS","family":"PETRI","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PALLE","family":"SVANHOLT","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BENI","family":"SOLOW","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GORDON","family":"WILDSCHI\u00d8DTZ","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PER","family":"WINKEL","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,6,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.312.7044.1472"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-134-8-200104170-00012"},{"key":"e_1_2_6_4_1","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1093\/sleep\/29.2.240","article-title":"Practice parameters for the treatment of snoring and obstructive sleep apnea with oral appliances: an update for 2005","volume":"29","author":"American Academy of Sleep Medicine","year":"2006","journal-title":"Sleep"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200311-1571OC"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-005-0003-4"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00045391-200201000-00011"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2109023"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.109.5.1269"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/29.2.244"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459988108900609"},{"key":"e_1_2_6_12_1","first-page":"721","article-title":"A new instrument for functional appliance bite construction","volume":"26","author":"George P. 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