{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T09:40:15Z","timestamp":1794217215066,"version":"4.8.0"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,10,7]],"date-time":"2008-10-07T00:00:00Z","timestamp":1223337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>A novel animal\u2010analog of the human psychomotor vigilance task (PVT) was validated by subjecting rats to 24\u2003h of sleep deprivation (SD) and examining the effect on performance in the rat\u2010PVT (rPVT), and a rat multiple sleep latency test (rMSLT). During a three\u2010phase (separate cohorts) crossover design, vigilance performance in the rPVT was compared with 24\u2003h SD\u2010induced changes in sleepiness assessed by polysomnographic evaluation and the rMSLT. Twenty\u2010four hours of SD was produced by brief rotation of activity wheels at regular intervals in which the animals resided throughout the experiment. In the rPVT experiment, exercise controls (EC) experienced the same overall amount of locomotor activity as during SD, but allowed long periods of undisturbed sleep. After 24\u2003h SD response latencies slowed, and lapses increased significantly during rPVT performance when compared with baseline and EC conditions. During the first 3\u2003h of the recovery period following 24\u2003h SD, polysomnographic measures indicated sleepiness. Latency to fall asleep after 24\u2003h SD was assessed six times during the first 3\u2003h after SD. Rats fell asleep significantly faster immediately after SD, than after non\u2010SD baseline sessions. In conclusion, 24\u2003h of SD in rats increased sleepiness, as indicated by polysomnography and the rMSLT, and impaired vigilance as measured by the rPVT. The rPVT closely resembles the human PVT test widely used in human sleep research and will assist investigation of the neurobiologic mechanisms that produce vigilance impairments after sleep disruption.<\/jats:p>","DOI":"10.1111\/j.1365-2869.2008.00698.x","type":"journal-article","created":{"date-parts":[[2008,10,7]],"date-time":"2008-10-07T07:17:20Z","timestamp":1223363840000},"page":"376-384","source":"Crossref","is-referenced-by-count":62,"title":["24\u2003hours of sleep deprivation in the rat increases sleepiness and decreases vigilance: introduction of the rat\u2010psychomotor vigilance task"],"prefix":"10.1111","volume":"17","author":[{"given":"MICHAEL A.","family":"CHRISTIE","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JAMES T.","family":"MCKENNA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NINA P.","family":"CONNOLLY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ROBERT W.","family":"MCCARLEY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ROBERT E.","family":"STRECKER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,11,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/29.1.55"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2869.2004.00407.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2869.2003.00337.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2181-06.2006"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00663111"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2466\/pms.1979.48.2.495"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/9.4.519"},{"key":"e_1_2_8_9_1","first-page":"69","article-title":"Sleep deprivation in rats produces attentional impairments on a 5\u2010choice serial reaction time task","volume":"29","author":"Cordova C. 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