{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T15:24:07Z","timestamp":1725031447439},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,9,2]],"date-time":"2011-09-02T00:00:00Z","timestamp":1314921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Obstructive sleep apnoea (OSA) is characterized by periods of upper airway collapse accompanied by repeated episodes of hypoxia. In experimental animals repeated bouts of hypoxia may evoke sustained augmentation of phrenic nerve activity, known as phrenic long\u2010term facilitation (pLTF). This form of physiological compensation might contribute to stable breathing, minimizing the occurrence of apnoeas and\/or hypopnoeas during sleep in patients with OSA. Serotonin (5\u2010HT) has been shown to modulate respiratory neuronal activity, possibly via projections originating in the raphe nuclei. Our model focuses on the effects of 5\u2010HT<jats:sub>1A<\/jats:sub> receptors blockade by selective antagonist WAY\u2010100635 into the caudal raphe region on phrenic long\u2010term facilitation after exposure to acute intermittent hypoxia (AIH) episodes. Adult, male, urethane\u2010anaesthetized, vagotomized, paralyzed and mechanically ventilated Sprague\u2013Dawley rats were exposed to AIH protocol. Experimental group received microinjection of WAY\u2010100635 into the caudal raphe nucleus, whereas the control group received saline into the same site. Peak phrenic nerve activity and respiratory rhythm parameters were analysed during five hypoxic episodes, as well as at 15, 30 and 60\u2003min after the end of hypoxias. In the control group, 1\u2003h post\u2010hypoxia pLTF was developed. Microinjections of selective 5\u2010HT<jats:sub>1A<\/jats:sub> receptor antagonist WAY\u2010100635 into the raphe nuclei prior to the AIH protocol prevented induction of pLTF. These results suggest that 5\u2010HT<jats:sub>1A<\/jats:sub> receptor activation at supraspinal level is important for induction of pLTF, which is suggested to be an important respiratory neuroplasticity model in animal studies that possibly correlates with OSA in humans.<\/jats:p>","DOI":"10.1111\/j.1365-2869.2011.00948.x","type":"journal-article","created":{"date-parts":[[2011,9,2]],"date-time":"2011-09-02T05:11:41Z","timestamp":1314940301000},"page":"195-203","source":"Crossref","is-referenced-by-count":7,"title":["Acute intermittent hypoxia induces phrenic long\u2010term facilitation which is modulated by 5\u2010HT<sub>1A<\/sub> receptor in the caudal raphe region of the rat"],"prefix":"10.1111","volume":"21","author":[{"given":"IVANA","family":"PAVLINAC DODIG","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RENATA","family":"PECOTIC","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MAJA","family":"VALIC","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ZORAN","family":"DOGAS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,9,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00476.2002"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(96)00017-5"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(01)00280-8"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-14-06239.2002"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2008.03.005"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(99)00010-6"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2006.08.001"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2009.12.011"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.90.5.2001"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2008.07.034"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1999.277.3.R658"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-20-08436.1998"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1095-6433(01)00393-2"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-14-05381.2001"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2011.01.011"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01952426"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2006.033720"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2008.045153"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2011.01.007"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00463.2003"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1986.sp016320"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.90.6.2466"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.2008.01853.x"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2010.10.005"},{"key":"e_1_2_6_26_1","volume-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos G. 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