{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:54:25Z","timestamp":1781110465758,"version":"3.54.1"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The long\u2010term survival of children with a central nervous system (CNS) tumour is improving. However, they experience late effects, including altered habits and patterns of sleep. We evaluated the presence and type of sleep disorders and daytime sleepiness in these children, and its associations with clinical characteristics and daily performance (fatigue and psychosocial functioning). In a cross\u2010sectional study at the outpatient clinic of the Emma Children\u2019s Hospital AMC (February\u2013June 2010), sleep, fatigue and psychosocial functioning were analysed in 31 CNS tumour patients (mean age: 11.8\u2003years; 20 boys) and compared with 78 patients treated for a non\u2010CNS malignancy (mean age: 9.7\u2003years; 41 boys) and norm data. Questionnaires applied were the Sleep Disorder Scale for Children, the Epworth Sleepiness Scale, the Pediatric Quality of Life Inventory, and the Strengths and Difficulties Questionnaire. Sleeping habits and endocrine deficiencies were assessed with a self\u2010developed questionnaire. Increased somnolence was found in CNS tumour patients compared with those with a non\u2010CNS malignancy (8.8\u2003\u00b1\u20032.8 versus 7.5\u2003\u00b1\u20032.7; <jats:italic>P\u2003<\/jats:italic>&lt;\u20030.05). Both patient groups reported more problems (<jats:italic>P\u2003<\/jats:italic>&lt;\u20030.01) than the norm with initiating and maintaining sleep. No specific risk factors were identified for a sleep disorder in CNS tumour patients, but their excessive somnolence was correlated with lower fatigue related quality of life (QoL) (<jats:italic>r\u2003<\/jats:italic>=\u2003\u22120.78, <jats:italic>P\u2003<\/jats:italic>&lt;\u20030.001) and worse psychosocial functioning (<jats:italic>r\u2003=\u2003<\/jats:italic>0.63, <jats:italic>P<\/jats:italic>\u2003&lt; 0.001). In conclusion, children treated for a CNS tumour have increased somnolence, significantly increasing fatigue and worsening daily functioning. Further investigation should focus on possibilities to improve sleep quality and diminish fatigue.<\/jats:p>","DOI":"10.1111\/j.1365-2869.2011.00971.x","type":"journal-article","created":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T07:47:38Z","timestamp":1317455258000},"page":"461-469","source":"Crossref","is-referenced-by-count":45,"title":["Sleep disorders in children after treatment for a CNS tumour"],"prefix":"10.1111","volume":"21","author":[{"given":"LISA M.","family":"VERBERNE","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HELEEN","family":"MAURICE\u2010STAM","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARTHA A.","family":"GROOTENHUIS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HANNEKE M.","family":"VAN SANTEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ANTOINETTE Y. 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