{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T09:15:33Z","timestamp":1717492533803},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,4,16]],"date-time":"2004-04-16T00:00:00Z","timestamp":1082073600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2004,4]]},"abstract":"<jats:p>High doses of dextromethorphan (DM) have been clinically investigated for the treatment of multiple neuronal disorders including neuropathic pain. Several authors have suggested the concomitant administration of DM and a CYP2D6 reversible inhibitor in order to enhance the exposure of DM and limit the exposure to total dextrorphan (DX). The present study proposes to determine whether or not a single dose of quinidine is sufficient to enhance the plasma concentrations of DM in rats and keep those of DX at a minimal level. Oral doses of DM (50\u2003mg\/kg) were administered with increasing dose levels of quinidine (0, 2, 20, and 50\u2003mg\/kg) to male Sprague\u2013Dawley rats and blood samples were collected over 24\u2003h. Plasma concentrations of DM and total DX were determined using ESI\u2010LC\/MS\/MS. Quinidine coadministration resulted in a more than twofold increase in the area under the curve of DM with an <jats:italic>ED<\/jats:italic><jats:sub>50<\/jats:sub> of approximately 2\u2003mg\/kg whereas those of total DX were only increased by 21%. These results support the working hypothesis that a single dose of quinidine may enhance the plasma concentrations of DM relative to those of total DX and may therefore improve the treatment of neuropathic pain.<\/jats:p>","DOI":"10.1111\/j.1365-2885.2004.00559.x","type":"journal-article","created":{"date-parts":[[2004,4,16]],"date-time":"2004-04-16T11:53:02Z","timestamp":1082116382000},"page":"111-114","source":"Crossref","is-referenced-by-count":9,"title":["Influence of concomitant quinidine administration on dextromethorphan disposition in rats"],"prefix":"10.1111","volume":"27","author":[{"given":"J. F.","family":"Marier","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. E.","family":"Pope","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. J.","family":"Yakatan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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