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The syndrome in dogs can consist of fever, arthropathy, blood dyscrasias (neutropenia, thrombocytopenia, or hemolytic anemia), hepatopathy consisting of cholestasis or necrosis, skin eruptions, uveitis, or keratoconjunctivitis sicca. Other manifestations seen less commonly include protein\u2010losing nephropathy, meningitis, pancreatitis, pneumonitis, or facial nerve palsy. The pathogenesis of these reactions is not completely understood, but may be due to a T\u2010cell\u2010mediated response to proteins haptenated by oxidative sulfonamide metabolites. Our laboratory is working on tests to characterize dogs with possible idiosyncratic sulfonamide reactions, to include ELISA for anti\u2010drug antibodies, immunoblotting for antibodies directed against liver proteins, flow cytometry for drug\u2010dependent anti\u2010platelet antibodies, and<jats:italic>in vitro<\/jats:italic>cytotoxicity assays. The management of idiosyncratic sulfonamide toxicity involves client education to identify clinical signs early and allow rapid drug discontinuation, supportive care to include possibly ascorbate and glutathione precursors, and avoidance of subsequent re\u2010exposure. It is important to realize that only antimicrobial sulfonamides, such as sulfamethoxazole, sulfadiazine, and sulfadimethoxine, share this clinical syndrome. There is no evidence for cross\u2010reactivity with drugs that have different underlying structures but share a sulfonamide moiety, such as acetazolamide, furosemide, glipizide, or hydrochlorthiazide.<\/jats:p>","DOI":"10.1111\/j.1365-2885.2004.00576.x","type":"journal-article","created":{"date-parts":[[2004,6,9]],"date-time":"2004-06-09T13:04:53Z","timestamp":1086786293000},"page":"129-138","source":"Crossref","is-referenced-by-count":115,"title":["Idiosyncratic toxicity associated with potentiated sulfonamides in the dog"],"prefix":"10.1111","volume":"27","author":[{"given":"L. 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