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Thermal threshold testing and blood collection were conducted simultaneously at predetermined time points. Plasma hydromorphone concentrations were determined by a liquid chromatographic\u2010mass spectral method and pharmacokinetic analysis was performed by nonlinear least squares regression analysis. Plasma hydromorphone concentrations declined rapidly over time, and were below the limit of quantification of the assay (LOQ\u2003=\u20031.0\u2003ng\/mL) by 360\u2003min. In contrast, thermal thresholds rose from a pretreatment value of 40.9\u2003\u00b1\u20030.65\u2003\u00b0C (mean\u2003\u00b1\u2003SEM) to instrument cut\u2010out (55\u2003\u00b0C) within 15\u2003min and remained significantly elevated from 15\u2013450\u2003min after treatment. Inspection of the data revealed no direct correlation between plasma hydromorphone concentrations and the antinociceptive effect of this drug in cats. These findings support the importance of conducting pharmacokinetic studies in parallel with objective measurements of drug effect.<\/jats:p>","DOI":"10.1111\/j.1365-2885.2004.00593.x","type":"journal-article","created":{"date-parts":[[2004,10,20]],"date-time":"2004-10-20T08:01:41Z","timestamp":1098259301000},"page":"329-336","source":"Crossref","is-referenced-by-count":57,"title":["Pharmacokinetic and pharmacodynamic evaluation of intravenous hydromorphone in cats<sup>1<\/sup>"],"prefix":"10.1111","volume":"27","author":[{"given":"K.","family":"Wegner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. A.","family":"Robertson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Kollias\u2010Baker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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