{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T18:31:04Z","timestamp":1776796264750,"version":"3.51.2"},"reference-count":56,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,2,18]],"date-time":"2005-02-18T00:00:00Z","timestamp":1108684800000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2005,2]]},"abstract":"<jats:p>Endotoxin is a potent stimulator of the inflammatory response and is believed to initiate the pathology in gram\u2010negative sepsis. Agents are being searched for that bind and neutralize or block the effects of endotoxin. The aim was to study the anti\u2010endotoxic effects of polymyxin\u2010E (colistin) in endotoxaemic dogs. The study included a total of 30 endotoxaemic dogs, which were divided into two groups (control\u2003=\u200315; test\u2003=\u200315) of both sexes, different breeds and ages. Hetastarch colloid solution (Expahes<jats:sup>\u00ae<\/jats:sup>,10\u2003mL\/kg, i.v.) with lactated Ringer's solution (20\u2003mL\/kg, i.v., Q12\u2003h) was given to all dogs. While ampicillin was administered (Alfasilin<jats:sup>\u00ae<\/jats:sup>, 10\u2003mg\/kg, i.m., Q12\u2003h) as an antibacterial to the control group, colistin (12\u2003500\u2003IU\/kg, i.m., Q12\u2003h)\u2003+\u2003ampicillin were administered to the test group. The clinical examination (body temperature, pulse and respiration rates, capillary filling times, peripheral pulse qualities, dehydration degrees), hematological and biochemical examinations (WBC, RBC, HGB, HCT, thrombocyte, serum urea, creatinine and TNF\u2010<jats:italic>\u03b1<\/jats:italic>) were performed both before the treatment, and 2, 4, 12 and 24\u2003h after the treatment. In comparison with the control group, it was observed that test group had shorter capillary filling time at 24\u2003h (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001). Moreover, the degree of dehydration in test group, was significantly improved at 24\u2003h (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.01). While the differences in peripheral pulse qualities significantly differed between 0 and 2\u2003h in controls, at 2, 4, 24\u2003h after treatment it was found to be significantly increased when compared with 0\u2003h in the test group. Serum TNF\u2010<jats:italic>\u03b1<\/jats:italic>concentrations were statistically decreased in the test group between 0\u2003h and other times (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.01). When compared with controls, serum TNF\u2010<jats:italic>\u03b1<\/jats:italic>concentrations were lower at 2, 4, 12 and 24\u2003h in test group (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05). Results of the study indicated that polymyxin\u2010E (colistin) has an anti\u2010endotoxic effect and is safe for the dogs with endotoxemia at the dosage used in this study.<\/jats:p>","DOI":"10.1111\/j.1365-2885.2004.00634.x","type":"journal-article","created":{"date-parts":[[2005,2,18]],"date-time":"2005-02-18T08:50:12Z","timestamp":1108716612000},"page":"57-63","source":"Crossref","is-referenced-by-count":23,"title":["Evaluation of the anti\u2010endotoxic effects of polymyxin\u2010E (colistin) in dogs with naturally occurred endotoxic shock"],"prefix":"10.1111","volume":"28","author":[{"given":"S.","family":"\u015eENT\u00dcRK","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,18]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Use of Polymyxin B for Equine Endotoxemia","author":"Barton M.H.","year":"2000"},{"key":"e_1_2_6_3_1","first-page":"339","article-title":"Effects of hypertonic 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