{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:55:27Z","timestamp":1787014527947,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,7,22]],"date-time":"2005-07-22T00:00:00Z","timestamp":1121990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2005,8]]},"abstract":"<jats:p>\n                    Clinically healthy mixed breed dogs (\n                    <jats:italic>n<\/jats:italic>\n                    \u2003=\u200320) were used to determine if a Tris (tromethamine)\u2010buffered test solution, Otinide\n                    <jats:sup>\u00ae<\/jats:sup>\n                    (Trademark of Dermcare\u2010Vet Pty\u2010Ltd, Australia), containing disodium ethylenediamine tetraacetic acid (EDTA; 1.21\u2003g\/L) and polyhexamethylene biguanide (PHMB; 0.22\u2003g\/L) caused ototoxicity or vestibular dysfunction. The dogs were randomly assigned to either a control group (group A,\n                    <jats:italic>n<\/jats:italic>\n                    \u2003=\u200310) receiving saline, or a treatment group (group B,\n                    <jats:italic>n<\/jats:italic>\n                    \u2003=\u200310) receiving the test solution. Phase 1 of the study consisted of applying 5.0\u2003mL of saline to both ears of the control group (group A) and 5\u2003mL of test solution to both ears of the test group (group B), for 21\u2003days. A bilateral myringotomy was then performed on each dog under deep sedation. Phase 2 of the study then consisted of applying 2.0\u2003mL of the saline to both ears of the control group (group A) and 2.0\u2003mL of the test solution to both ears of the test group (group B), for 14\u2003days. Throughout the study, dogs were examined for clinical health, and underwent otoscopic, vestibular and auditory examinations. The auditory examinations included brainstem auditory evoked potential (BAEP) threshold and supra\u2010threshold assessments using both click and 8\u2003kHz tone burst stimuli. The absence of vestibular signs and effects on the BAEP attributable to the test solution suggested the test solution could be applied safely to dogs, including those with a damaged tympanic membrane.\n                  <\/jats:p>","DOI":"10.1111\/j.1365-2885.2005.00672.x","type":"journal-article","created":{"date-parts":[[2005,7,22]],"date-time":"2005-07-22T13:37:40Z","timestamp":1122039460000},"page":"391-397","source":"Crossref","is-referenced-by-count":20,"title":["Ototoxicity and tolerance assessment of a TrisEDTA and polyhexamethylene biguanide ear flush formulation in dogs"],"prefix":"10.1111","volume":"28","author":[{"given":"P. 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