{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T04:59:51Z","timestamp":1794286791751,"version":"4.9.0"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,10,5]],"date-time":"2005-10-05T00:00:00Z","timestamp":1128470400000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2005,10]]},"abstract":"<jats:p>The pharmacokinetics and thermal antinociceptive effects of buprenorphine after intravenous (i.v.) or oral transmucosal (OTM) administration were studied in six adult cats. Plasma buprenorphine concentrations were measured using radioimmunoassay in a crossover study after a dose of 20\u2003<jats:italic>\u03bc<\/jats:italic>g\/kg given by the i.v. or OTM route. Oral pH was measured. Blood for drug analyses was collected before, and at 1, 2, 4, 6, 10, 15, 30, and 60\u2003min and at 2, 4, 6, 8, 12, and 24\u2003h after treatment. Thermal thresholds were measured before treatment, then following treatment every 30\u2003min to 6\u2003h, every 1 hour to 12\u2003h and at 24\u2003hours postadministration. Plasma buprenorphine concentration effect relationships were analyzed using a log\u2010linear effect model. Oral pH was 9 in each cat. Peak plasma buprenorphine concentration was lower and occurred later in the OTM group but median bioavailability was 116.3%. Thermal thresholds increased significantly between 30 and 360\u2003min in both groups. Peak effect was at 90\u2003min and there was no difference at any time between the two groups. There was distinct hysteresis between plasma drug concentration and effect in both groups. Overall, OTM administration of buprenorphine is as effective as i.v. treatment and offers a simple, noninvasive method of administration which produces thermal antinociception for up to 6\u2003h in cats.<\/jats:p>","DOI":"10.1111\/j.1365-2885.2005.00677.x","type":"journal-article","created":{"date-parts":[[2005,10,5]],"date-time":"2005-10-05T12:24:36Z","timestamp":1128515076000},"page":"453-460","source":"Crossref","is-referenced-by-count":169,"title":["PK\u2010PD modeling of buprenorphine in cats: intravenous and oral transmucosal administration<sup>1<\/sup>"],"prefix":"10.1111","volume":"28","author":[{"given":"S. A.","family":"ROBERTSON","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. D. X.","family":"LASCELLES","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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