{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T18:58:30Z","timestamp":1789153110174,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,11,2]],"date-time":"2006-11-02T00:00:00Z","timestamp":1162425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:p>\n                    This study compared pressure and thermal thresholds after administration of three opioids in eight cats. Pressure stimulation was performed via a bracelet taped around the forearm. Three ball\u2010bearings were advanced against the forearm by inflation of a modified blood pressure bladder. Pressure in the cuff was recorded at the end point (leg shake and head turn). Thermal threshold was tested as previously reported using a heated probe held against the thorax [\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#b6\">\n                      Dixon\n                      <jats:italic>et\u00a0al<\/jats:italic>\n                      . (2002)\n                    <\/jats:ext-link>\n                    <jats:italic>Research in Veterinary Science<\/jats:italic>\n                    ,\n                    <jats:bold>72<\/jats:bold>\n                    , 205]. After baseline recordings, each cat received subcutaneous methadone 0.2\u2003mg\/kg, morphine 0.2\u2003mg\/kg, buprenorphine 0.02\u2003mg\/kg or saline 0.3\u2003mL in a four period cross\u2010over study. Measurements were made at 15, 30, 45\u2003min and 1, 2, 3, 4, 8, 12 and 24\u2003h after the injection. Data were analysed by\n                    <jats:sc>anova<\/jats:sc>\n                    (\n                    <jats:italic>P<\/jats:italic>\n                    \u2003&lt;\u20030.05). There were no significant changes in thresholds after saline. Thermal threshold increased at 45\u2003min after buprenorphine (maximum 2.8\u2003\u00b1\u20033\u2003\u00b0C), 1\u20133\u2003h after methadone (maximum 3.4\u2003\u00b1\u20031.9\u2003\u00b0C) and 45\u2003min to 1\u2003h (maximum 3.4\u2003\u00b1\u20032\u2003\u00b0C) after morphine. Pressure threshold increased 30\u201345\u2003min (maximum 238\u2003\u00b1\u2003206\u2003mmHg) after buprenorphine, 45\u201360\u2003min after methadone (maximum 255\u2003\u00b1\u2003232\u2003mmHg) and 45\u201360\u2003min and 3\u20136\u2003h (maximum 255\u2003\u00b1\u2003232\u2003mmHg) after morphine. Morphine provided the best analgesia, and methadone appears a promising alternative. Buprenorphines limited effect was probably related to the subcutaneous route of administration. Previously, buprenorphine has produced much greater effects when given by other routes.\n                  <\/jats:p>","DOI":"10.1111\/j.1365-2885.2006.00800.x","type":"journal-article","created":{"date-parts":[[2006,11,2]],"date-time":"2006-11-02T18:03:13Z","timestamp":1162490593000},"page":"531-537","source":"Crossref","is-referenced-by-count":83,"title":["Effects of subcutaneous methadone, morphine, buprenorphine or saline on thermal and pressure thresholds in cats"],"prefix":"10.1111","volume":"29","author":[{"given":"P. V. M.","family":"STEAGALL","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"CARNICELLI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. M.","family":"TAYLOR","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. P. L.","family":"LUNA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"DIXON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. H.","family":"FERREIRA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,11,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2987.2004.00148.x"},{"key":"e_1_2_6_3_1","first-page":"111","volume-title":"Anaesthesia of the Cat","author":"Brearley J.C.","year":"1994"},{"key":"e_1_2_6_4_1","first-page":"196","volume-title":"Principles and Practice of Pharmacolgy for Anaesthetists","author":"Calvey T.N.","year":"2001"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-200006000-00009"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1977.tb07533.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/rvsc.2001.0543"},{"key":"e_1_2_6_8_1","article-title":"Development of a pressure nociceptive threshold testing device for evaluation of analgesics in cats","author":"Dixon M.J.","year":"2006","journal-title":"Research in Veterinary Science"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.5326\/0380507"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1993.tb02588.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-7020-1767-4.50007-2"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1096-2867(97)80007-2"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2987.2004.00175.x"},{"key":"e_1_2_6_14_1","first-page":"434","article-title":"Pharmacology of methadone and its isomers","volume":"71","author":"Inturrisi C.E.","year":"2005","journal-title":"Minerva Anestesiologica"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.4102\/jsava.v72i1.613"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2004.tb00159.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2004.65.1085"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/inpract.19.4.203"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.145.21.601"},{"key":"e_1_2_6_20_1","first-page":"125","volume-title":"Essentials of Small Animal Anesthesia and Analgesia","author":"Lemke K.","year":"1999"},{"key":"e_1_2_6_21_1","article-title":"Use of a transdermal matrix patch of buprenorphine in cats: Preliminary kinetic and dynamic data","author":"Murrell J.C.","year":"2006","journal-title":"Veterinary Record"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(08)70005-6"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1090-0233(02)00186-7"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2004.08.001"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2003.10.002"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.153.15.462"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.152.22.675"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.2004.00628.x"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.2005.00677.x"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.143.7.185"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1467-2987.2001.00062.x"},{"key":"e_1_2_6_32_1","first-page":"78","volume-title":"Pressure and Thermal Threshold in Cats after Administration of Tramadol, Acepromazine, Tramadol with Acepromazine or Saline","author":"Steagall P.V.M.","year":"2005"},{"key":"e_1_2_6_33_1","article-title":"The effects of buprenorphine, carprofen and saline on thermal and mechanical nonciceptive thresholds in cats","author":"Steagall P.V.M.","year":"2006","journal-title":"Veterinary Anaesthesia and Analgesia"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2885.2001.368goblin.x"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.2004.00593.x"},{"key":"e_1_2_6_36_1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1080\/00480169.2005.36504","article-title":"Current attitudes to, and use of, perioperative analgesia in dogs and cats by veterinarians in New Zealand","volume":"53","author":"Williams V.M.","year":"2005","journal-title":"New Zealand Journal"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1053\/svms.2002.36609"}],"container-title":["Journal of Veterinary Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2885.2006.00800.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2885.2006.00800.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T16:46:06Z","timestamp":1697042766000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2885.2006.00800.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11,2]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["10.1111\/j.1365-2885.2006.00800.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2885.2006.00800.x","archive":["Portico"],"relation":{},"ISSN":["0140-7783","1365-2885"],"issn-type":[{"value":"0140-7783","type":"print"},{"value":"1365-2885","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11,2]]}}}