{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:01:21Z","timestamp":1791313281260,"version":"4.3.1"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,11,2]],"date-time":"2006-11-02T00:00:00Z","timestamp":1162425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:p>Tissue cages (TC), implanted subcutaneously in the neck in eight ponies, were inoculated with <jats:italic>Staphylococcus aureus<\/jats:italic> (<jats:italic>S. aureus<\/jats:italic>) to determine the clinical efficacy of marbofloxacin in the treatment of this infection. From 21\u2003h after inoculation, marbofloxacin (6\u2003mg\/kg) was administered intravenously (i.v.) once daily for 7\u2003days. Samples of the tissue cage fluid (TCF) were taken to determine marbofloxacin concentrations (days 1, 3 and 7), using high\u2010pressure liquid chromatography, and numbers of viable bacteria [colony forming units (CFU)] (days 1, 3, 7, 14 and 21). Statistical analysis was used to compare CFU before and after treatment. Clinical signs and CFU were used to evaluate the efficacy of treatment. Although, there was a slight decrease in CFU in all TC initially, the infection was not eliminated by marbofloxacin treatment in any of the ponies and abscesses formed. As the <jats:italic>MIC<\/jats:italic> (0.25\u2003<jats:italic>\u03bc<\/jats:italic>g\/mL) did not change during treatment and the concentration of marbofloxacin during treatment (mean concentration in TCF was 0.89\u2003<jats:italic>\u03bc<\/jats:italic>g\/mL on day 1, 0.80\u2003<jats:italic>\u03bc<\/jats:italic>g\/mL on day 3 and 2.77\u2003<jats:italic>\u03bc<\/jats:italic>g\/mL on day 7) was above <jats:italic>MIC<\/jats:italic>, we consider that the treatment failure might be attributable to the formation of a biofilm by <jats:italic>S. aureus<\/jats:italic>. Based on the present results, i.v. administration of marbofloxacin alone is not suitable for the elimination of <jats:italic>S. aureus<\/jats:italic> infections from secluded sites.<\/jats:p>","DOI":"10.1111\/j.1365-2885.2006.00803.x","type":"journal-article","created":{"date-parts":[[2006,11,2]],"date-time":"2006-11-02T23:03:13Z","timestamp":1162508593000},"page":"555-560","source":"Crossref","is-referenced-by-count":12,"title":["Clinical efficacy of intravenous administration of marbofloxacin in a <i>Staphylococcus aureus<\/i> infection in tissue cages in ponies"],"prefix":"10.1111","volume":"29","author":[{"given":"M.","family":"VOERMANS","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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