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After injection of amoxicillin\/clavulanic acid through the distal port of the catheter, analysis of drug components in the simultaneous blood samples obtained by the proximal port and a Venoject<jats:sup>\u00ae<\/jats:sup>system were comparable in one pig. Histological control of the catheterized jugular veins pointed to an acceptable tissue reaction while bacteriological examination of the tip of the catheters was negative in only three animals. A moulding of the intestinal veins was made in a pig cadaver to determine the optimal length of insertion of a silicone portal catheter from the splenic vein towards the portal vein. Surgery was straightforward in four pigs whereby the catheter was exteriorized towards the back region. No complications were encountered during and after surgery for 9\u2003days. The technique of a double\u2010lumen catheter placed into the jugular vein and a transsplenic portal catheter is a useful tool for the study of the pharmacokinetics and also the first\u2010pass effect of drugs in experimental pigs.<\/jats:p>","DOI":"10.1111\/j.1365-2885.2008.01012.x","type":"journal-article","created":{"date-parts":[[2008,8,29]],"date-time":"2008-08-29T07:38:16Z","timestamp":1219995496000},"page":"137-145","source":"Crossref","is-referenced-by-count":20,"title":["Transsplenic portal catheterization combined with a jugular double\u2010lumen catheter for pharmacokinetic and presystemic metabolization studies in pigs"],"prefix":"10.1111","volume":"32","author":[{"given":"F.","family":"GASTHUYS","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"DE BOEVER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"SCHAUVLIEGE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"REYNS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"LEVET","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"CORNILLIE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"CASTELEYN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"DE BACKER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"CROUBELS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,3,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2885.1998.00107.x"},{"key":"e_1_2_6_3_1","first-page":"431","article-title":"Vascular\u2010access\u2010port implantation for serial blood sampling in conscious swine","volume":"36","author":"Bailie M.B.","year":"1986","journal-title":"Laboratory Animal Science"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/08860220500199084"},{"key":"e_1_2_6_5_1","first-page":"669","volume-title":"Anatomie Compar\u00e9e des Mammif\u00e8res Domestiques. 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