{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:24:40Z","timestamp":1760783080202},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,10,7]],"date-time":"2008-10-07T00:00:00Z","timestamp":1223337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2009,4]]},"abstract":"<jats:p>The physicochemical properties, p<jats:italic>K<\/jats:italic><jats:sub>a<\/jats:sub>, Log <jats:italic>P<\/jats:italic> and solubility of compound alpha, (5\u2010chloro\u20102\u2010(methylthio)\u20106\u2010(1\u2010naphthyloxy)\u20101<jats:italic>H<\/jats:italic>\u2010benzimidazole), a new fasciolicide agent, were characterized using conventional methods. Also, its pharmacokinetics was evaluated in sheep and cattle. In both species an oral dose of 12\u2003mg\/kg was administered. Blood samples were collected during 144\u2003h and analyzed by using an HPLC assay. Results showed that compound alpha is a weak base with a p<jats:italic>K<\/jats:italic><jats:sub>a<\/jats:sub> value of 2.87 and log <jats:italic>P<\/jats:italic> of 1.44. The solubility was very low in aqueous solvents. Pharmacokinetic studies showed that in both species compound alpha could not be detected at any sampling time. The mean half\u2010life (<jats:italic>t<\/jats:italic><jats:sub>\u00bd<\/jats:sub>) values of alpha sulphoxide in sheep and cattle were 19.86 and 29.87\u2003h, while the half\u2010life values of alpha sulphone were 19.43 and 46.32\u2003h respectively. <jats:italic>C<\/jats:italic><jats:sub>max<\/jats:sub> values of alpha sulphoxide did not differ between species while alpha sulphone values were higher in cattle. Plasma protein binding of alpha sulphoxide was between 82% and 86%. These results, combined with the previous efficacy studies, suggest that compound alpha could be a promising fasciolicide agent.<\/jats:p>","DOI":"10.1111\/j.1365-2885.2008.01014.x","type":"journal-article","created":{"date-parts":[[2008,10,7]],"date-time":"2008-10-07T06:58:10Z","timestamp":1223362690000},"page":"154-159","source":"Crossref","is-referenced-by-count":12,"title":["Pharmacokinetic behavior in sheep and cattle of 5\u2010chloro\u20102\u2010(methylthio)\u20106\u2010(1\u2010naphthyloxy)\u20101<i>H<\/i>\u2010benzimidazole, a new fasciolicide agent"],"prefix":"10.1111","volume":"32","author":[{"given":"N.","family":"RAM\u00cdREZ","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"MAYET","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"DEL 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