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Robenacoxib, at a dosage of 2\u2003mg\/kg administered subcutaneously, was evaluated in a kaolin\u2010induced paw inflammation model in 10 cats, using both clinically relevant endpoints (lameness scoring, locomotion tests) and other indicators of inflammation (body and skin temperature, thermal pain threshold) to establish its pharmacological profile. A pharmacokinetic\/pharmacodynamic (PK\/PD) modelling approach, based on indirect response models, was used to describe the time course and magnitude of the responses to robenacoxib. All endpoints demonstrated good responsiveness to robenacoxib administration and both the magnitude and time courses of responses were well described by the indirect pharmacodynamic response models. Pharmacokinetic and clinically relevant pharmacodynamic parameters were used to simulate dosage regimens that will assist the planning of clinical trials and the selection of an optimal dosage regimen for robenacoxib in the cat.<\/jats:p>","DOI":"10.1111\/j.1365-2885.2008.01016.x","type":"journal-article","created":{"date-parts":[[2009,1,13]],"date-time":"2009-01-13T08:11:56Z","timestamp":1231834316000},"page":"18-30","source":"Crossref","is-referenced-by-count":48,"title":["Use of a pharmacokinetic\/pharmacodynamic approach in the cat to determine a dosage regimen for the COX\u20102 selective drug robenacoxib"],"prefix":"10.1111","volume":"32","author":[{"given":"J. M.","family":"GIRAUDEL","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. N.","family":"KING","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. 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