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Derivatives of 4\u2010AP have been tested in models of spinal cord injury in guinea pigs; three derivatives (methyl\u2010, ethyl\u2010 and <jats:italic>t<\/jats:italic>\u2010butyl carbamate derivatives) showed promise. This study investigates the safety and pharmacokinetics of these derivatives in dogs. Each derivative was administered orally to dogs starting at doses below effective doses in guinea pigs, and increasing the dose on sequential days. Routine blood work was performed prior to and 24\u2003h after drug administration, blood samples were collected at intervals over 24\u2003h after drug administration, and dogs were monitored for side effects. Derivative plasma levels were determined using high\u2010pressure liquid chromatography. Cerebrospinal fluid (CSF) samples were taken to determine CSF levels. No adverse effects were seen even when using doses higher than those that improved conduction in spinal cord injured guinea pigs. Peak plasma levels occurred at 36.6 (ethyl), 87 (<jats:italic>t<\/jats:italic>\u2010butyl) and 175 (methyl)\u2003min and plasma level was related to drug dose. Penetration of the central nervous system (CNS) was good, with CSF levels higher than plasma levels for the <jats:italic>t<\/jats:italic>\u2010butyl derivative.<\/jats:p>","DOI":"10.1111\/j.1365-2885.2009.01072.x","type":"journal-article","created":{"date-parts":[[2009,4,20]],"date-time":"2009-04-20T08:18:03Z","timestamp":1240215483000},"page":"485-491","source":"Crossref","is-referenced-by-count":4,"title":["Pharmacokinetics of 4\u2010aminopyridine derivatives in dogs"],"prefix":"10.1111","volume":"32","author":[{"given":"N. J.","family":"OLBY","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. 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