{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T23:34:27Z","timestamp":1793489667696,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2010,4,19]],"date-time":"2010-04-19T00:00:00Z","timestamp":1271635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:p>Mealey, K.L., Waiting, D., Raunig, D.L., Schmidt, K.R., Nelson, F.R. Oral bioavailability of P\u2010glycoprotein substrate drugs do not differ between<jats:italic>ABCB<\/jats:italic>1\u20101\u0394 and<jats:italic>ABCB<\/jats:italic>1 wild type dogs.<jats:italic>J. vet. Pharmacol. Therap<\/jats:italic>.<jats:bold>33<\/jats:bold>, 453\u2013460.<\/jats:p><jats:p>Previous studies have indicated that intestinal P\u2010glycoprotein (P\u2010gp) limits the oral bioavailability of substrate drugs and alters systemic pharmacokinetics. In this study, dogs lacking functional P\u2010gp were used to determine the contribution of P\u2010gp to the oral bioavailability and systemic pharmacokinetics of several P\u2010gp substrate drugs. The P\u2010gp substrates quinidine, loperamide, nelfinavir, cyclosporin and the control (non P\u2010gp substrate) drug diazepam were individually administered intravenously and per os to<jats:italic>ABCB<\/jats:italic>1\u20101\u0394 dogs, which have a P\u2010gp null phenotype and<jats:italic>ABCB<\/jats:italic>1 wildtype dogs.<jats:italic>ABCB<\/jats:italic>1\u20101\u0394 dogs have been shown to have greater brain penetration of P\u2010gp substrates, but limited information is available regarding oral bioavailability of P\u2010gp substrate drugs in this animal model. Plasma drug concentration vs. time curves were generated and pharmacokinetic parameters were calculated for each drug. There were no differences in oral bioavailability between<jats:italic>ABCB<\/jats:italic>1\u20101\u0394 dogs and<jats:italic>ABCB<\/jats:italic>1 wildtype dogs for any of the drugs studied, suggesting that intestinal P\u2010gp does not significantly affect intestinal absorption of these particular substrate drugs in ABCB1\u20101\u0394 dogs. However, small sample sizes and individual variability in CYP enzyme activity may have affected the power of the study to detect the impact of P\u2010gp on oral bioavailability.<\/jats:p>","DOI":"10.1111\/j.1365-2885.2010.01170.x","type":"journal-article","created":{"date-parts":[[2010,4,19]],"date-time":"2010-04-19T16:06:25Z","timestamp":1271693185000},"page":"453-460","source":"Crossref","is-referenced-by-count":27,"title":["Oral bioavailability of P\u2010glycoprotein substrate drugs do not differ between<i>ABCB<\/i>1\u20101\u0394 and<i>ABCB<\/i>1 wild type dogs"],"prefix":"10.1111","volume":"33","author":[{"given":"K. 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