{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T19:11:52Z","timestamp":1773688312350,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2010,11,22]],"date-time":"2010-11-22T00:00:00Z","timestamp":1290384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:p>Sidhu, P. K., Landoni, M. F., Aliabadi, M. H. S., Toutain, P. L., Lees, P. Pharmacokinetic and pharmacodynamic modelling of marbofloxacin administered alone and in combination with tolfenamic acid in calves. <jats:italic>J. vet. Pharmacol. Therap.<\/jats:italic><jats:bold>34<\/jats:bold>, 376\u2013387.<\/jats:p><jats:p>In a four\u2010period, cross\u2010over study, the fluoroquinolone antibacterial drug marbofloxacin (MB) was administered to calves, alone and in combination with the nonsteroidal anti\u2010inflammatory drug tolfenamic acid (TA). Both drugs were administered intramuscularly (IM) at doses of 2\u2003mg\/kg. A tissue cage model of inflammation, based on the actions of the mild irritant carrageenan, was used to evaluate the pharmacokinetics (PK) of MB and MB in combination with TA. MB mean values of area under concentration\u2013time curve (AUC) were 15.1\u2003\u03bcg\u00b7h\/mL for serum, 12.1\u2003\u03bcg\u00b7h\/mL for inflamed tissue cage fluid (exudate) and 9.6\u2003\u03bcg\u00b7h\/mL for noninflamed tissue cage fluid (transudate). Values of <jats:italic>C<\/jats:italic><jats:sub>max<\/jats:sub> were 1.84, 0.35 and 0.31\u2003\u03bcg\/mL, respectively, for serum, exudate and transudate. Mean residence time (MRT) of 23.6\u2003h (exudate) and 22.6\u2003h (transudate) also differed significantly from serum MRT (8.6\u2003h). Co\u2010administration of TA did not affect the PK profile of MB. The pharmacodynamics of MB was investigated using a bovine strain of <jats:italic>Mannheimia haemolytica<\/jats:italic>. Time\u2013kill curves were established <jats:italic>ex vivo<\/jats:italic> on serum, exudate and transudate samples. Modelling the <jats:italic>ex vivo<\/jats:italic> serum time\u2013kill data to the sigmoid E<jats:sub>max<\/jats:sub> equation provided AUC<jats:sub>24\u2003h<\/jats:sub>\/MIC values required for bacteriostatic (18.3\u2003h) and bactericidal actions (92\u2003h) of MB and for virtual eradication of the organism was 139\u2003h. Corresponding values for MB\u2003+\u2003TA were 20.1, 69 and 106\u2003h. These data were used to predict once daily dosage schedules for a bactericidal action, assuming a MIC<jats:sub>90<\/jats:sub> value of 0.24\u2003\u03bcg\/mL, a dose of 2.6\u2003mg\/kg for MB and 2.19\u2003mg\/kg for MB\u2003+\u2003TA were determined, which are similar to the currently recommended dose of 2.0\u2003mg\/kg.<\/jats:p>","DOI":"10.1111\/j.1365-2885.2010.01247.x","type":"journal-article","created":{"date-parts":[[2010,11,23]],"date-time":"2010-11-23T03:22:24Z","timestamp":1290482544000},"page":"376-387","source":"Crossref","is-referenced-by-count":33,"title":["Pharmacokinetic and pharmacodynamic modelling of marbofloxacin administered alone and in combination with tolfenamic acid in calves"],"prefix":"10.1111","volume":"34","author":[{"given":"P. K.","family":"SIDHU","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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