{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T01:04:52Z","timestamp":1773450292784,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,2,17]],"date-time":"2011-02-17T00:00:00Z","timestamp":1297900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:p>Bellei, E., Roncada, P., Pisoni, L., Joechler, M., Zaghini, A. The use of fentanyl\u2010patch in dogs undergoing spinal surgery: plasma concentrations and analgesic efficacy.<jats:italic>J. vet. Pharmacol. Therap.<\/jats:italic><jats:bold>34<\/jats:bold>, 437\u2013441.<\/jats:p><jats:p>Objectives of this study were to evaluate plasma concentrations and analgesic efficacy of fentanyl administered transdermically in dogs undergoing spinal surgery. At the end of the surgery and before awakening, a fentanyl\u2010patch was applied and was maintained<jats:italic>in situ<\/jats:italic>for 72\u2003h. Blood samples were taken before the application of the patch, at 2, 4, 6, 8, 10, 12, 18, 24, 32, 40, 48, 60, and 72\u2003h after application and then 2, 4, 6, 8, 10, and 12\u2003h after its removal. Before each blood sampling, pain evaluation was carried out using the Glasgow pain score, appropriately modified. Plasma concentrations of fentanyl were determined using a specific immuno\u2010enzymatic kit. In this study, the minimum analgesic plasma concentration (0.23\u2003ng\/mL) required to achieve analgesia in human and considered to apply also for dogs was reached in all animals. No animal showed pain in the range of \u2018intense pain\u2019; in two cases, the level of the pain was slight or moderate. No undesired effects were found. Results suggest that the use of transdermic patches could represent a valid aid in pain therapy in small animals; in particular, it contributes to the postoperative well\u2010being of patients undergoing major surgery.<\/jats:p>","DOI":"10.1111\/j.1365-2885.2010.01263.x","type":"journal-article","created":{"date-parts":[[2011,2,17]],"date-time":"2011-02-17T07:09:53Z","timestamp":1297926593000},"page":"437-441","source":"Crossref","is-referenced-by-count":15,"title":["The use of fentanyl\u2010patch in dogs undergoing spinal surgery: plasma concentration and analgesic efficacy"],"prefix":"10.1111","volume":"34","author":[{"given":"E.","family":"BELLEI","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"RONCADA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"PISONI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"JOECHLER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"ZAGHINI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,2,17]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198412000-00018"},{"key":"e_1_2_5_3_1","first-page":"1","volume-title":"Small Animal Pain Management","author":"Carroll G.L.","year":"1998"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.1998.tb00114.x"},{"key":"e_1_2_5_5_1","first-page":"651","article-title":"Development of a scale to evaluate postoperative pain in dogs","volume":"214","author":"Firth A.M.","year":"1999","journal-title":"Journal of the American Animal Hospital Association"},{"key":"e_1_2_5_6_1","first-page":"21","article-title":"Postoperative pain management using fentanyl patch in dogs","volume":"42","author":"Gilberto D.B.","year":"2003","journal-title":"Contemporary Topics in Laboratory Animal Science"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200038010-00004"},{"key":"e_1_2_5_8_1","first-page":"82","volume-title":"The Handbook of Veterinary Pain Management","author":"Hellyer P.W.","year":"2002"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.5326\/0430235"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.5326\/0400468"},{"key":"e_1_2_5_11_1","first-page":"61","article-title":"Comparison of three methods used for assessment of pain in dogs","volume":"212","author":"Holton L.L.","year":"1998","journal-title":"Journal of the American Animal Hospital Association"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/inpract.21.3.111"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2009.02115.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"crossref","first-page":"715","DOI":"10.2460\/ajvr.1996.57.05.715","article-title":"Disposition of transdermally administered fentanyl in dogs","volume":"57","author":"Kyles A.E.","year":"1996","journal-title":"American Journal of Veterinary Research"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.1999.5789"},{"key":"e_1_2_5_16_1","volume-title":"Small Animal Anesthesia & Analgesia","author":"McKelvey D.","year":"2003"},{"key":"e_1_2_5_17_1","first-page":"473","article-title":"Anesthesia for dogs and cats with cardiovascular disease. 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