{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T22:32:55Z","timestamp":1778279575501,"version":"3.51.4"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,6,22]],"date-time":"2011-06-22T00:00:00Z","timestamp":1308700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p>KuKanich, B., Nauss, J. L. Pharmacokinetics of the cytochrome P\u2010450 substrates phenytoin, theophylline, and diazepam in healthy Greyhound dogs.<jats:italic>J. vet. Pharmacol. Therap.<\/jats:italic>\u00a0<jats:bold>35<\/jats:bold>, 275\u2013281.<\/jats:p><jats:p>The purpose of this study was to determine the pharmacokinetics of phenytoin, theophylline, and diazepam in six healthy Greyhound dogs. Additionally, the pharmacokinetics of the diazepam metabolites, oxazepam and nordiazepam, after diazepam administration was determined. Phenytoin sodium (12\u2003mg\/kg), aminophylline (10\u2003mg\/kg), and diazepam (0.5\u2003mg\/kg) were administered IV on separate occasions, and blood was collected at predetermined time points for the quantification of plasma drug concentrations by florescence polarization immunoassay (phenytoin, theophylline) or mass spectrometry (diazepam, oxazepam, and nordiazepam). The terminal half\u2010life was 4.9, 9.2, and 1.0\u2003h, respectively, for phenytoin, theophylline, and diazepam, and 6.2 and 2.4\u2003h for oxazepam and nordiazepam after IV diazepam. The clearance was of 2.37, 0.935, and 27.9\u2003mL\u00b7min\/kg, respectively, for phenytoin, theophylline, and diazepam. The<jats:italic>C<\/jats:italic><jats:sub>MAX<\/jats:sub>was 44.7 and 305.2\u2003ng\/mL for oxazepam and nordiazepam, respectively, after diazepam administration. Temazepam was not detected above 5\u2003ng\/mL in any sample after IV diazepam.<\/jats:p>","DOI":"10.1111\/j.1365-2885.2011.01316.x","type":"journal-article","created":{"date-parts":[[2011,6,22]],"date-time":"2011-06-22T09:32:14Z","timestamp":1308735134000},"page":"275-281","source":"Crossref","is-referenced-by-count":11,"title":["Pharmacokinetics of the cytochrome P\u2010450 substrates phenytoin, theophylline, and diazepam in healthy Greyhound dogs"],"prefix":"10.1111","volume":"35","author":[{"given":"B.","family":"KuKANICH","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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