{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T02:22:18Z","timestamp":1794363738839,"version":"4.9.0"},"reference-count":20,"publisher":"Wiley","issue":"s2","license":[{"start":{"date-parts":[[2012,6,25]],"date-time":"2012-06-25T00:00:00Z","timestamp":1340582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p>Linton, D. D., Wilson, M. G., Newbound, G. C., Freise, K. J., Clark, T. P. The effectiveness of a long\u2010acting transdermal fentanyl solution compared to buprenorphine for the control of postoperative pain in dogs in a randomized, multicentered clinical study. <jats:italic>J. vet. Pharmacol. Therap.<\/jats:italic><jats:bold>35<\/jats:bold> (Suppl. 2), 53\u201364.<\/jats:p><jats:p>A prospective, double\u2010blinded, positive\u2010controlled, multicenter, noninferiority clinical study was conducted to evaluate the safety and effectiveness of a long\u2010acting transdermal fentanyl solution (TFS) for the control of postoperative pain. Four hundred forty\u2010five client\u2010owned dogs of various breeds were randomly assigned to receive a single dose of TFS (2.6\u2003mg\/kg [\u223c50\u2003\u03bcL\/kg]) (<jats:italic>N<\/jats:italic>\u2003=\u2003223) applied 2\u20134\u2003h prior to surgery or buprenorphine (20\u2003\u03bcg\/kg) (<jats:italic>N<\/jats:italic>\u2003=\u2003222) administered intramuscularly 2\u20134\u2003h prior to surgery and every 6\u2003h through 90\u2003h. There were 159 (35.7%) males and 286 (64.3%) females ranging from 0.5 to 16\u2003years of age and 3 to 98.5\u2003kg enrolled. Pain was scored using the modified Glasgow Composite Pain Scale with an <jats:italic>a priori<\/jats:italic> dropout criteria of \u22658 (20 maximum score). The one\u2010sided upper 95% confidence interval of the mean difference between fentanyl and buprenorphine treatment failures was 5.6%, which was not greater than the <jats:italic>a priori<\/jats:italic> selected margin difference of 15%. Adverse events attributed to either treatment were minimal in impact and were approximately equal between groups. Sustained plasma fentanyl concentrations provided by a single pre\u2010emptive dose of TFS are safe and effective and are noninferior to repeated injections of buprenorphine in controlling postoperative pain over 4\u2003days. This long\u2010acting fentanyl formulation provides veterinarians with a novel, registered option for the control of postoperative pain in dogs that improves dosing compliance and potentially mitigates the disadvantages of oral, parenteral, and patch delivered opioids.<\/jats:p>","DOI":"10.1111\/j.1365-2885.2012.01408.x","type":"journal-article","created":{"date-parts":[[2012,6,25]],"date-time":"2012-06-25T18:04:42Z","timestamp":1340647482000},"page":"53-64","source":"Crossref","is-referenced-by-count":38,"title":["The effectiveness of a long\u2010acting transdermal fentanyl solution compared to buprenorphine for the control of postoperative pain in dogs in a randomized, multicentered clinical study"],"prefix":"10.1111","volume":"35","author":[{"given":"D. D.","family":"LINTON","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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