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In this study, the tissue distribution and transcriptional modulation of solute carrier (<jats:styled-content style=\"fixed-case\">SLC<\/jats:styled-content>) and<jats:styled-content style=\"fixed-case\">ATP<\/jats:styled-content>\u2010binding cassette (<jats:styled-content style=\"fixed-case\">ABC<\/jats:styled-content>)<jats:styled-content style=\"fixed-case\">DT<\/jats:styled-content>s were investigated in cattle orally administered with phenobarbital (<jats:styled-content style=\"fixed-case\">PB<\/jats:styled-content>) by using a quantitative real\u2010time<jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>approach. The criterion for target gene selection was the<jats:styled-content style=\"fixed-case\">PB<\/jats:styled-content>\u2010responsiveness in human and rodent model species. All target DTs were expressed in the liver. Only two of the seven<jats:styled-content style=\"fixed-case\">PB<\/jats:styled-content>\u2010responsive target<jats:styled-content style=\"fixed-case\">DT<\/jats:styled-content>s (<jats:styled-content style=\"fixed-case\">SLCO<\/jats:styled-content>1<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>3 and<jats:styled-content style=\"fixed-case\">SLC<\/jats:styled-content>10<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>1) were not constitutively expressed in cattle extra\u2010hepatic tissues. The greatest number of<jats:styled-content style=\"fixed-case\">DT<\/jats:styled-content>s (<jats:styled-content style=\"fixed-case\">SLCO<\/jats:styled-content>2<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>1,<jats:styled-content style=\"fixed-case\">ABCB<\/jats:styled-content>1,<jats:styled-content style=\"fixed-case\">ABCC<\/jats:styled-content>2,<jats:styled-content style=\"fixed-case\">ABCG<\/jats:styled-content>2) were expressed in intestine and testis, followed by, adrenal gland (<jats:styled-content style=\"fixed-case\">SLCO<\/jats:styled-content>2<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>1,<jats:styled-content style=\"fixed-case\">ABCB<\/jats:styled-content>1,<jats:styled-content style=\"fixed-case\">ABCG<\/jats:styled-content>2), lung (<jats:styled-content style=\"fixed-case\">ABCB<\/jats:styled-content>1,<jats:styled-content style=\"fixed-case\">ABCG<\/jats:styled-content>2), kidney, and skeletal muscle (<jats:styled-content style=\"fixed-case\">ABCG<\/jats:styled-content>2). PB administration never altered<jats:styled-content style=\"fixed-case\">DT<\/jats:styled-content>s m<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>levels, except for an increase in hepatic<jats:styled-content style=\"fixed-case\">ABCC<\/jats:styled-content>2 m<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>and a down\u2010regulation of renal<jats:styled-content style=\"fixed-case\">ABCG<\/jats:styled-content>2. Altogether, these results confirm only to some extent data obtained in humans and laboratory species; clearly, they should be considered a preliminary step for further molecular investigations about species\u2010differences in<jats:styled-content style=\"fixed-case\">DT<\/jats:styled-content>gene expression and regulation as well as in<jats:styled-content style=\"fixed-case\">DT<\/jats:styled-content>expression and function.<\/jats:p>","DOI":"10.1111\/j.1365-2885.2012.01427.x","type":"journal-article","created":{"date-parts":[[2012,8,16]],"date-time":"2012-08-16T10:07:14Z","timestamp":1345111634000},"page":"358-369","source":"Crossref","is-referenced-by-count":8,"title":["Tissue distribution and phenobarbital induction of target SLC\u2010 and<scp>ABC<\/scp>\u2010 transporters in cattle"],"prefix":"10.1111","volume":"36","author":[{"given":"V.","family":"Zancanella","sequence":"first","affiliation":[{"name":"Dipartimento di Biomedicina Comparata e Alimentazione viale dell'Universit\u00e0 16 Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Giantin","sequence":"additional","affiliation":[{"name":"Dipartimento di Biomedicina Comparata e Alimentazione viale dell'Universit\u00e0 16 Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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