{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T15:50:21Z","timestamp":1761580221835},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,6,29]],"date-time":"2004-06-29T00:00:00Z","timestamp":1088467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2004,7]]},"abstract":"<jats:p><jats:bold>Summary.\u2002<\/jats:bold> Nowadays it is clear that chemokine\u2013chemokine receptor interactions are important in chronic hepatitis C virus (HCV) infection. The objective of the present study was to elucidate the involvement of the <jats:italic>CCR5<\/jats:italic>\u2010\u039432 and <jats:italic>CCR2\u2010<\/jats:italic>V64I polymorphisms in the response to the HCV infection, as well as in the histological damage and the outcome of the infection. A cohort of 139 patients with hepatitis C and 100 healthy blood donors were analysed for both polymorphisms using real\u2010time polymerase chain reaction (PCR) and LightCycler<jats:sup>TM<\/jats:sup> technology. We have detected the <jats:italic>CCR5<\/jats:italic>\u2010\u039432 allele in 15 of 278 HCV chromosomes (5.4%) and 15 of 200 control chromosomes (7.5%). The <jats:italic>CCR2\u2010<\/jats:italic>V64I allele was present in 24 of 278 HCV chromosomes (8.6%) and 19 of 200 control chromosomes (9.5%). Analysis of the histological parameters showed no statistical significance when comparing the patients carrying the variants <jats:italic>vs<\/jats:italic> the cases with the wild\u2010type allele. Our results seem to indicate that the <jats:italic>CCR5<\/jats:italic>\u2010\u039432 and <jats:italic>CCR2<\/jats:italic>\u2010V64I polymorphisms are not related to the response to HCV infection, histological damage and outcome of infection in our cohort of Spanish HCV patients.<\/jats:p>","DOI":"10.1111\/j.1365-2893.2004.00510.x","type":"journal-article","created":{"date-parts":[[2004,7,2]],"date-time":"2004-07-02T06:10:41Z","timestamp":1088748641000},"page":"319-323","source":"Crossref","is-referenced-by-count":21,"title":["Analysis of <i>CCR5<\/i>\u2010\u039432 and <i>CCR2<\/i>\u2010V64I polymorphisms in a cohort of Spanish HCV patients using Real\u2010time Polymerase Chain Reaction and Fluorescence Resonance Energy Transfer technologies"],"prefix":"10.1111","volume":"11","author":[{"given":"M.","family":"Ruiz\u2010Ferrer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Barroso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Anti\u00f1olo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Aguilar\u2010Reina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,6,29]]},"reference":[{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/33340"},{"key":"e_1_2_11_3_2","first-page":"145","article-title":"International union of pharmacology XXII. 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