{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T07:01:45Z","timestamp":1765609305136},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2006,2,20]],"date-time":"2006-02-20T00:00:00Z","timestamp":1140393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:p><jats:bold>Summary.\u2002<\/jats:bold> Insulin resistance (IR) is a common condition in chronic hepatitis C. Recent studies have reported that IR is associated with liver fibrosis progression in these patients. However, there is no information available on this issue in human immunodeficiency virus (HIV)\/hepatitis C virus (HCV)\u2010coinfected patients. For these reasons, we investigate the relationship between IR and liver fibrosis in patients with HIV and HCV infections. This was a cross\u2010sectional study where patients from an Infectious Diseases Unit with HIV\/HCV coinfection who underwent a liver biopsy, with available frozen sera samples at the time of biopsy and a known or estimated date of infection were included. IR was determined by the homeostasis model assessment (HOMA\u2010IR) method. The relationship between histological findings and several variables, including HOMA\u2010IR values, was examined. Seventy\u2010nine patients fulfilled the inclusion criteria. Age at HCV infection &gt;21\u2003years was the only variable independently associated with advanced liver fibrosis (stages F3 and F4) [adjusted odds ratio (AOR) 4.15; 95% confidence interval (CI) 1.5\u201311.3]. The variables associated with a fibrosis progression rate above the median were age at HCV infection &gt;21\u2003years (AOR 6.41; 95% CI 2.16\u201327.96) and previous exposure to nevirapine (AOR 8.9; 95% CI 2.01\u201339.36). There was no association between HOMA\u2010IR values and the presence of advanced fibrosis or a faster fibrosis progression. Thus IR is not associated with liver damage or fibrosis progression in HIV\/HCV\u2010coinfected individuals.<\/jats:p>","DOI":"10.1111\/j.1365-2893.2005.00708.x","type":"journal-article","created":{"date-parts":[[2006,2,20]],"date-time":"2006-02-20T16:56:41Z","timestamp":1140454601000},"page":"449-456","source":"Crossref","is-referenced-by-count":15,"title":["Insulin resistance is not associated with liver fibrosis progression in HIV\/hepatitis C virus\u2010coinfected patients"],"prefix":"10.1111","volume":"13","author":[{"given":"N.","family":"Merchante","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Mac\u00edas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Ramayo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Vergara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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