{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T19:04:51Z","timestamp":1793387091290,"version":"4.5.0"},"reference-count":102,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,11,10]],"date-time":"2006-11-10T00:00:00Z","timestamp":1163116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:p><jats:bold>Summary.\u2002<\/jats:bold> The importance of treating hepatitis C virus (HCV)\u2010associated morbidities in a growing population of patients coinfected with human immunodeficiency virus (HIV) has increased since the introduction of highly active antiretroviral therapy. As a result, investigative attention is turning to HCV\u2010related liver disease and treatment\u2010associated issues in coinfection. HIV\/HCV\u2010coinfected patients have higher HCV RNA loads and show more rapid progression of fibrosis than do monoinfected patients. Combination therapy with pegylated interferon plus ribavirin (RBV) is the standard of care for HCV in coinfected patients. Therapy slows fibrosis progression, but toxicity prevents identification of the most effective RBV dose. Coinfected patients have about a threefold greater risk of antiretroviral therapy\u2010associated hepatotoxicity than patients with HIV only. Other challenges include anaemia, mitochondrial toxicity, drug\u2013drug interactions and leucopenia. Thus, chronic hepatitis C should be treated in HIV\/HCV\u2010coinfected patients, but steps must be taken to prevent and treat potential toxicities. The first European Consensus Conference on the Treatment of Chronic Hepatitis B and C in HIV Co\u2010infected Patients was held March 2005 in Paris to address these issues. This article reviews the peer\u2010reviewed literature and expert opinion published from 1990 to 2005, and compares results with presentations and recommendations from the Consensus Conference to best present current issues in coinfection.<\/jats:p>","DOI":"10.1111\/j.1365-2893.2006.00816.x","type":"journal-article","created":{"date-parts":[[2006,11,10]],"date-time":"2006-11-10T14:40:29Z","timestamp":1163169629000},"page":"371-386","source":"Crossref","is-referenced-by-count":67,"title":["Therapeutic issues in HIV\/HCV\u2010coinfected patients"],"prefix":"10.1111","volume":"14","author":[{"given":"M. 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