{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T13:47:24Z","timestamp":1768312044271,"version":"3.49.0"},"reference-count":16,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2006,12,21]],"date-time":"2006-12-21T00:00:00Z","timestamp":1166659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:p><jats:bold>Summary.\u2002<\/jats:bold> Bacteremia has rarely been reported in patients receiving treatment for hepatitis C virus (HCV) infection. We describe the features and investigation of four cases of <jats:italic>Staphylococcus aureus<\/jats:italic> bacteremia occurring between 3 November 2004 and 10 January 2005 in patients on therapy for chronic HCV infection. The unusual occurrence of <jats:italic>S. aureus<\/jats:italic> bacteremia in a series of patients led to an epidemiologic investigation and molecular typing methods were employed to assess the relatedness of cases. The mean time of bacteremia onset was week 10 of HCV treatment. No patient had neutropenia previously. The average duration of bacteremia was 2.6\u2003days and complications included acute renal failure (2\/4), disseminated intravascular coagulopathy (DIC) with sepsis syndrome (1\/4), septic arthritis (1\/4), spinal epidural abscess (1\/4) and endocarditis (1\/4). Two patients were in the same weight class for dosing, but no other epidemiologic links were found. One patient admitted to intravenous drug use (IVDU) and a second was suspected of IVDU. The two other patients were cirrhotic, but had no further identifiable risk factors. All bacterial isolates were methicillin\u2010susceptible. By pulsed\u2010field gel electrophoresis, two cases were found to have identical bacterial strains. However, fluorescent\u2010based amplified fragment\u2010length polymorphism analysis demonstrated distinct band patterns in all four cases. The epidemiologic data and molecular analysis of this cluster of <jats:italic>S. aureus<\/jats:italic> bacteremia cases among patients receiving combination therapy for treatment of chronic HCV infection suggest that these cases were not related. Additionally, IVDU and cirrhosis, but not neutropenia, are identified as potential risk factors for this uncommon complication of HCV therapy.<\/jats:p>","DOI":"10.1111\/j.1365-2893.2006.00828.x","type":"journal-article","created":{"date-parts":[[2006,12,21]],"date-time":"2006-12-21T14:13:10Z","timestamp":1166710390000},"page":"564-569","source":"Crossref","is-referenced-by-count":6,"title":["<i>Staphylococcus aureus<\/i> bacteremia in patients receiving pegylated interferon\u2010alpha and ribavirin for chronic hepatitis C virus infection"],"prefix":"10.1111","volume":"14","author":[{"given":"D.","family":"Webster","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Tandon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Chui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. R.","family":"McDonald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Obarianyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Antonishyn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Doucette","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,12,21]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-140-5-200403020-00010"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020047"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06102-5"},{"key":"e_1_2_8_5_2","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1177\/135965350400900417","article-title":"Use of pegylated interferons is associated with an increased incidence of infections during combination treatment of chronic hepatitis C: a side effect of pegylation","volume":"9","author":"Puoti M","year":"2004","journal-title":"Antiviral Ther"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)83539-4"},{"key":"e_1_2_8_7_2","article-title":"Pegylated interferon (alpha\u20102B) and ribavirin (Rebetrol) for the treatment of HCV infected patients who failed prior therapy: sustained response data","volume":"126","author":"Gaglio PJ","year":"2004","journal-title":"Gastroenterology"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840200104"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.10.3481-3485.2001"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.33.9.2233-2239.1995"},{"key":"e_1_2_8_11_2","doi-asserted-by":"crossref","first-page":"4058","DOI":"10.1128\/JCM.38.11.4058-4065.2000","article-title":"Evaluation of fluorescence\u2010based amplified fragment length polymorphism analysis for molecular typing in hospital epidemiology: comparison with pulsed\u2010field gel electrophoresis for typing strains of vancomycin\u2010resistant Enterococcus faecium","volume":"38","author":"Antonishyn NA","year":"2000","journal-title":"J Clin Microbiol"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5520(01)00003-4"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2004.0934.x"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(99)80070-1"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-50-7-588"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.11.4980-4985.2003"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-7012(99)00023-8"}],"container-title":["Journal of Viral Hepatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2893.2006.00828.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2893.2006.00828.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T16:55:50Z","timestamp":1697043350000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2893.2006.00828.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12,21]]},"references-count":16,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2007,8]]}},"alternative-id":["10.1111\/j.1365-2893.2006.00828.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2893.2006.00828.x","archive":["Portico"],"relation":{},"ISSN":["1352-0504","1365-2893"],"issn-type":[{"value":"1352-0504","type":"print"},{"value":"1365-2893","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,12,21]]}}}