{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T17:04:58Z","timestamp":1765731898329},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2007,1,3]],"date-time":"2007-01-03T00:00:00Z","timestamp":1167782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:p><jats:bold>Summary.\u2002<\/jats:bold> Chronic hepatitis C virus (HCV) infection leads to mixed cryoglobulinaemia (MC) and B\u2010cell non\u2010Hodgkin lymphoma (B\u2010NHL). Aberrant somatic hypermutation and deregulation of the oncogene BCL\u20106 is associated with lymphomagenesis. Recently, HCV was shown to induce BCL\u20106 mutations <jats:italic>in vitro<\/jats:italic>. The BCL\u20106 gene (area B) was cloned and sequenced from peripheral blood mononuclear cells (PBMC) of 21 chronically HCV\u2010infected patients with or without MC and B\u2010NHL, and six healthy controls. Mutational frequencies, genetic complexity and diversity were calculated. BCL\u20106 mRNA from PBMC was quantified by real\u2010time polymerase chain reaction, and additional sustained virologic responders to antiviral therapy and HBV patients served as controls. The overall\/recurrent mutational frequencies tended to be lower in MC and B\u2010NHL patients when compared with controls (<jats:italic>P<\/jats:italic>\u2003=\u20030.15 and 0.06, respectively). Genetic complexity was significantly lower in MC and B\u2010NHL patients (<jats:italic>P<\/jats:italic>\u2003=\u20030.025). BCL\u20106 mRNA concentration was decreased in all HCV patients when compared with healthy controls, sustained virologic responder and HBV patients (<jats:italic>P<\/jats:italic>\u2003=\u20030.005). Although HCV can induce BCL\u20106 mutations <jats:italic>in vitro<\/jats:italic>, lower mutational frequencies and decreased BCL\u20106 mRNA expression <jats:italic>in vivo<\/jats:italic> suggest no major role of aberrant somatic hypermutation in HCV\u2010associated MC and B\u2010NHL.<\/jats:p>","DOI":"10.1111\/j.1365-2893.2006.00833.x","type":"journal-article","created":{"date-parts":[[2007,1,4]],"date-time":"2007-01-04T13:47:57Z","timestamp":1167918477000},"page":"484-491","source":"Crossref","is-referenced-by-count":11,"title":["Somatic hypermutation and mRNA expression levels of the BCL\u20106 gene in patients with hepatitis C virus\u2010associated lymphoproliferative diseases*"],"prefix":"10.1111","volume":"14","author":[{"given":"W. 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