{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T08:38:07Z","timestamp":1784709487820,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2007,4,30]],"date-time":"2007-04-30T00:00:00Z","timestamp":1177891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:p><jats:bold>Summary.\u2002<\/jats:bold>Adiponectin possesses anti\u2010inflammatory, insulin\u2010sensitizing and anti\u2010atherosclerotic properties. The aim of this study was to assess the levels of serum adiponectin in patients with chronic viral hepatitis C and B and correlate them with parameters exploring insulin resistance and indices of chronic liver disease. Seventy\u2010two patients with chronic hepatitis C virus (HCV) infection and 73 patients with chronic hepatitis B virus (HBV) infection, matched for age and sex, were studied. All individuals were examined for serum concentrations of adiponectin, insulin, C\u2010peptide and homeostasis model assessment for insulin resistance (HOMA\u2010IR). Viral parameters and liver histology were also evaluated. Serum adiponectin levels were significantly higher in HCV compared with HBV\u2010infected patients. Correlation analysis in the whole group demonstrated that serum adiponectin was positively correlated with aspartate aminotransferase, alkaline phosphatase, globulins, high\u2010density lipoprotein cholesterol and staging score, while it was negatively correlated with body mass index, insulin, C\u2010peptide and HOMA\u2010IR. Logistic regression analysis identified type of infection (HCV<jats:italic>vs<\/jats:italic>HBV), alcohol consumption more than 25\u2003g daily, serum total globulin and low C\u2010peptide as significant predictive variables associated with high adiponectin levels. Higher levels of serum adiponectin in HCV compared with HBV patients could have a role in the slower disease progression of chronic HCV infection. In addition, alcohol intake more than 25\u2003g daily seems to be a significant predictor for hyperadiponectinaemia in patients with chronic viral hepatitis C or B. Finally, in this study, a clear positive association between adiponectin and hepatic necroinflammation or staging score was not found.<\/jats:p>","DOI":"10.1111\/j.1365-2893.2007.00850.x","type":"journal-article","created":{"date-parts":[[2007,5,7]],"date-time":"2007-05-07T12:41:31Z","timestamp":1178541691000},"page":"577-583","source":"Crossref","is-referenced-by-count":28,"title":["Serum adiponectin in chronic hepatitis C and B"],"prefix":"10.1111","volume":"14","author":[{"given":"D.","family":"Siagris","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Vafiadis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Michalaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Lekkou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Starakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Makri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Margaritis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Christofidou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. C.","family":"Tsamandas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Labropoulou\u2010Karatza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,4,30]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.5.7463"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/90992"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2003.12.058"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2004.04.010"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncpendmet0190"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031315"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.01821"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2004.03.003"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2006.02527.x"},{"key":"e_1_2_6_11_2","first-page":"1","article-title":"The postprandial phase as a link between systemic lipid peroxidation and liver injury in NASH","volume":"101","author":"Musso G","year":"2006","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.11.1296"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000119921.86460.37"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200317797"},{"key":"e_1_2_6_15_2","first-page":"476","article-title":"Glucose homeostasis in chronic viral hepatitis and liver cirrhosis","volume":"27","author":"Custro N","year":"2001","journal-title":"Diabetes Metab"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2003.08.032"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1266"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.05.030"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.02.044"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.00311.x"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00494.2003"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i34.5490"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/18.6.499"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8529(05)70360-1"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280883"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8278(95)80226-6"},{"key":"e_1_2_6_27_2","first-page":"246","article-title":"Diagnosis and interpretation of steatosis and steatohepatitis","volume":"15","author":"Burt AD","year":"1998","journal-title":"Semin Diagn Pathol"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20280"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.037010"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1999.0255"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2004.12.024"},{"issue":"1","key":"e_1_2_6_32_2","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/hep.1840360706","article-title":"Natural history of chronic hepatitis C","volume":"36","author":"Seeff LB","year":"2002","journal-title":"Hepatology"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.5507\/bp.2005.011"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)91122-K"}],"container-title":["Journal of Viral Hepatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2893.2007.00850.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2893.2007.00850.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T02:28:51Z","timestamp":1736994531000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2893.2007.00850.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4,30]]},"references-count":33,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2007,8]]}},"alternative-id":["10.1111\/j.1365-2893.2007.00850.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2893.2007.00850.x","archive":["Portico"],"relation":{},"ISSN":["1352-0504","1365-2893"],"issn-type":[{"value":"1352-0504","type":"print"},{"value":"1365-2893","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,4,30]]}}}