{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T18:15:29Z","timestamp":1788459329005,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2007,7,27]],"date-time":"2007-07-27T00:00:00Z","timestamp":1185494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:p><jats:bold>Summary.\u2002<\/jats:bold> Considerable evidence suggests that host genetic factor play an important role in the pathogenesis and clinical outcome of chronic hepatitis B virus (HBV) infection in several ethic groups. Association study was performed included 150 chronic HBV patients, 100 resolved hepatitis B and 150 healthy individuals with similar ethic background. Interestingly, human leucocyte antigen (HLA)\u2010DR13 show a strong association with the clearance of HBV [odds ratio (OR)\u2003=\u20030.04, 95% confidence interval (CI)\u2003=\u20030.00\u20130.26, corrected <jats:italic>P<\/jats:italic>\u2010value (<jats:italic>P<\/jats:italic><jats:sub>c<\/jats:sub>)\u2003=\u20030.0008] similar to reports from several ethic groups. TNF\u2010\u03b1 promoter polymorphisms (\u2212863, \u2212308 and \u2212238) were also analysed. Only \u2212863 C allele was found to be significantly decreased in chronic HBV patients compared with healthy control (<jats:italic>P<\/jats:italic><jats:sub>c<\/jats:sub>\u2003=\u20030.03, OR\u2003=\u20030.54, 95% CI\u2003=\u20030.35\u20130.84 respectively). This \u2212863C allele was not in linkage disequilibrium with HLA\u2010DR13 suggesting that other genetic markers linked with \u2212863C might influence clearance of chronic HBV infection in Thai. When stratified chronic HBV patients into patients without hepatocellular carcinoma (HCC) and with HCC, the \u2212863 A allele was significantly increased in the HCC group compared to healthy control (<jats:italic>P<\/jats:italic><jats:sub>c<\/jats:sub>\u2003=\u20030.003, OR\u2003=\u20032.61, 95% CI\u2003=\u20031.49\u20134.60). Haplotype analysis (\u2212863\/\u2212308\/\u2212238) revealed that the homozygosity of the haplotype (CGG\/CGG) was a protective marker for HCC (OR\u2003=\u20030.37, 95% CI\u2003=\u20030.17\u20130.79, <jats:italic>P<\/jats:italic><jats:sub>c<\/jats:sub>\u2003=\u20030.02). One can propose that carriers of \u2212863A genotype are associated with increased levels of TNF\u2010\u03b1 in the liver in response to HBV infection and induce hapatocyte damage that may finally lead to HCC development. Additional study is needed to validate these finding and to further explore the genetic pathogenesis of HBV infection.<\/jats:p>","DOI":"10.1111\/j.1365-2893.2007.00880.x","type":"journal-article","created":{"date-parts":[[2007,7,27]],"date-time":"2007-07-27T19:19:26Z","timestamp":1185563966000},"page":"841-848","source":"Crossref","is-referenced-by-count":81,"title":["Association of HLA\u2010DRB1*13 and TNF\u2010\u03b1 gene polymorphisms with clearance of chronic hepatitis B infection and risk of hepatocellular carcinoma in Thai 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