{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:21:16Z","timestamp":1777900876789,"version":"3.51.4"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,12,5]],"date-time":"2007-12-05T00:00:00Z","timestamp":1196812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:p><jats:bold>Summary.\u2002<\/jats:bold> Knowing the likely distribution of intervals from hepatitis C infection to first RNA\u2010negativity is important in deciding about therapeutic intervention. Prospectively collected sera and data from the Transfusion\u2010transmitted Viruses Study (1974\u20131980) provide specific dates of infection and pattern of alanine aminotransferase (ALT) elevations. We examined frequency, timing and correlates of spontaneous resolution for 94 acutely infected transfusion recipients followed for a median of 9.5\u2003months. Later, follow\u2010up sera (&gt;10\u2003years) were available for 27 of the 94 cases from a Veterans Administration (VA) Study (1989\u20131990). Twenty\u2010five (27%) of the 94 cases were classified as probably resolved during the episode itself. First RNA negativity occurred at 6\u201350\u2003weeks (median, 19.5\u2003weeks) after infection, and 5\u201343\u2003weeks (median, 11\u2003weeks) after ALT elevation. Thirteen of the 25 cases remained RNA\u2010negative subsequently; 12 others had 1\u20136 RNA\u2010positive sera intercalated between first and last RNA\u2010negative results. RNA negativity, therefore, began variably and was interrupted in 12 cases of 25 (48%) by transient RNA\u2010positive sera. Five of these 25 patients who were RNA\u2010negative in the last study specimen had late, Veterans Administration Study follow\u2010up; none showed viraemia. Of the remaining 69 transfusion transmitted virus study recipients, whose last serum was RNA\u2010positive, two cleared viraemia after the last study serum but before late follow\u2010up. Eleven (16%) had 23 intercalated RNA\u2010negative sera before last positivity. RNA status, therefore, needs monitoring for many months before judging the spontaneous outcome as transient negativity may occur. Resolution was significantly more common in women and symptomatic cases; it was not associated with viral load in the infectious donation, HCV genotype, or the recipient\u2019s age.<\/jats:p>","DOI":"10.1111\/j.1365-2893.2007.00900.x","type":"journal-article","created":{"date-parts":[[2010,8,4]],"date-time":"2010-08-04T13:05:25Z","timestamp":1280927125000},"page":"120-128","source":"Crossref","is-referenced-by-count":44,"title":["The course of hepatitis C viraemia in transfusion recipients prior to availability of antiviral therapy"],"prefix":"10.1111","volume":"15","author":[{"given":"J. W.","family":"Mosley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. A.","family":"Operskalski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. H.","family":"Tobler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z. J.","family":"Buskell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. W.","family":"Andrews","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Phelps","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Dockter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Giachetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. B.","family":"Seeff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. P.","family":"Busch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the Transfusion\u2010transmitted Viruses Study and Retrovirus Epidemiology Donor Study Groups","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,12,5]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2005.05.003"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(03)00008-4"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20119"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011232"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)00668-1"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20196"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20266"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21043"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)00394-9"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2004.12.012"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21085"},{"key":"e_1_2_7_13_2","first-page":"33","volume-title":"Blood Safety in the New Millennium","author":"Busch MP","year":"2001"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20742"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.21905"},{"key":"e_1_2_7_16_2","first-page":"361","volume-title":"Viral Hepatitis; 1981 International Symposium","author":"Hollinger FB","year":"1982"},{"key":"e_1_2_7_17_2","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1093\/ajcp\/44.5_ts.591","article-title":"Stability of serum glutamic pyruvic transaminase activity on storage","volume":"44","author":"Mosley JW","year":"1965","journal-title":"Am J Clin Pathol"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2003.00475.x"},{"key":"e_1_2_7_19_2","first-page":"121A","article-title":"Long term stability of HIV\u20101 and HCV specimens collected in different anticoagulants and stored at \u221220\u00b0C or \u221270\u00b0C","volume":"41","author":"Dockter J","year":"2003","journal-title":"Transfusion"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-132-2-200001180-00003"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.7.2408-2419.2002"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.6.2590-2597.2005"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.08.016"},{"key":"e_1_2_7_24_2","first-page":"1","article-title":"Sensitivity of second\u2010generation enzyme immunoassay for detection of hepatitis C virus infection among oncology patients","volume":"35","author":"Macedo Oliveira A","year":"2006","journal-title":"J Clin Virol"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510270333"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(00)00456-3"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.1995.tb00016.x"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.10.1395"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.8.2860-2863.2001"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-130-2-199901190-00007"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-142-11-200506070-00007"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.36129"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/155.7.645"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/171.4.768"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.037788"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2003.00355.x"},{"key":"e_1_2_7_37_2","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1128\/JCM.36.4.872-877.1998","article-title":"Different hepatitis C virus (HCV) RNA load profiles following seroconversion among injecting drug users without correlation with HCV genotype and serum alanine aminotransferase","volume":"36","author":"Beld M","year":"1998","journal-title":"J Clin Microbiol"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1590-8658(03)00007-0"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118842"},{"key":"e_1_2_7_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70353-7"},{"key":"e_1_2_7_41_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.202608299"},{"key":"e_1_2_7_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840210306"},{"key":"e_1_2_7_43_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2004.00505.x"}],"container-title":["Journal of Viral Hepatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2893.2007.00900.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2893.2007.00900.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T00:34:48Z","timestamp":1696984488000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2893.2007.00900.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12,5]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,2]]}},"alternative-id":["10.1111\/j.1365-2893.2007.00900.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2893.2007.00900.x","archive":["Portico"],"relation":{},"ISSN":["1352-0504","1365-2893"],"issn-type":[{"value":"1352-0504","type":"print"},{"value":"1365-2893","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12,5]]}}}