{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T02:39:16Z","timestamp":1783651156116,"version":"3.55.0"},"reference-count":55,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2008,2,6]],"date-time":"2008-02-06T00:00:00Z","timestamp":1202256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:p><jats:bold>Summary.\u2002<\/jats:bold> Eosinophilic infiltrate of liver tissue is described in primary cholestatic diseases, hepatic allograft rejection and drug\u2010induced liver injury, but its significance and its implications in chronic hepatitis C are unknown. The aim of this study was to investigate the clinical significance of eosinophilic liver infiltrate in patients with chronic hepatitis C. We retrospectively evaluated 147 patients with chronic hepatitis C. The presence of eosinophilic infiltrate was investigated in liver biopsies, and a numeric count of eosinophilic leucocytes in every portal tract was assessed. An eosinophilic infiltrate of liver tissue (\u22653 cells evaluated in the portal\u200a\/\u200aperiportal spaces) was observed in 46 patients (31%), and patients who consumed drugs had an odds ratio (OR) of 4.02 (95%\u2003CI: 1.62\u20139.96) to have an eosinophilic infiltrate in liver biopsy. By logistic regression analysis, the presence of steatosis was independently associated with eosinophilic infiltrate (OR 5.86; 95%\u2003CI: 2.46\u201313.96) and homeostasis model assessment\u2010score (OR 1.18; 95%\u2003CI: 1.00\u20131.39). Logistic regression analysis also showed that fibrosis staging \u2265 2 by Scheuer score was associated with grading &gt;1 by Scheuer score (OR 6.82; 95%\u2003CI 2.46\u201318.80) and eosinophilic infiltrate (OR 4.00; 95%\u2003CI 1.23\u201312.91). In conclusion, we observed that the eosinophilic infiltrate of liver tissue was significantly more frequent in patients who assumed drugs, and found a significant association between eosinophilic infiltrate, liver steatosis and liver fibrosis. These preliminary data could lead to a constant assumption of drugs as a co\u2010factor of eosinophils\u2010mediated liver injury in chronic hepatitis C.<\/jats:p>","DOI":"10.1111\/j.1365-2893.2008.00976.x","type":"journal-article","created":{"date-parts":[[2008,2,6]],"date-time":"2008-02-06T08:04:02Z","timestamp":1202285042000},"page":"523-530","source":"Crossref","is-referenced-by-count":23,"title":["Liver eosinophilic infiltrate is a significant finding in patients with chronic hepatitis 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