{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T08:58:57Z","timestamp":1772009937141,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2008,7,10]],"date-time":"2008-07-10T00:00:00Z","timestamp":1215648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:p><jats:bold>Summary.\u2002<\/jats:bold> Antiviral treatment results in a sustained virologic response (SVR) in 50\u201375% of patients with chronic hepatitis C. Long\u2010term follow up studies have observed ongoing SVR in the overwhelming majority of them. Thus chronic hepatitis C is considered \u2018cured\u2019 if an SVR is achieved. Consequently, it is expected that in sustained virologic responders long\u2010term complications of hepatatic C virus (HCV) related chronic liver disease including hepatocellular carcinoma are eliminated or have a decreased incidence. We report on five patients (three from Austria, two from USA) who developed hepatocellular carcinoma during follow up (3\u20136\u2003years) after achieving SVR. During follow up and at diagnosis all were HCV\u2010RNA neg. None of the patients had other liver diseases. One patient presented with bilateral adrenal metastasis, the remaining four with large hepatic tumours. Three patients were noncirrhotic at the start of treatment at the time of tumour diagnosis. Successful antiviral treatment in HCV patients does not prevent development of hepatocellular carcinoma even in non\u2010cirrhotic livers. Long\u2010term follow up of patients with SVR is mandatory and should include surveillance for hepatocellular carcinoma.<\/jats:p>","DOI":"10.1111\/j.1365-2893.2008.01006.x","type":"journal-article","created":{"date-parts":[[2008,7,10]],"date-time":"2008-07-10T07:03:49Z","timestamp":1215673429000},"page":"659-665","source":"Crossref","is-referenced-by-count":19,"title":["Hepatocellular carcinoma in long\u2010term sustained virological responders following antiviral combination therapy for chronic hepatitis C"],"prefix":"10.1111","volume":"15","author":[{"given":"T.\u2010M.","family":"Scherzer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. 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