{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T11:57:04Z","timestamp":1763726224452},"reference-count":23,"publisher":"Wiley","issue":"s2","license":[{"start":{"date-parts":[[2008,8,27]],"date-time":"2008-08-27T00:00:00Z","timestamp":1219795200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:p><jats:bold>Summary.\u2002<\/jats:bold> Universal hepatitis A (HA) vaccination was implemented by the Argentinean Ministry of Health in June 2005 with a single dose at age 12\u2003months. The decision was made taking into account the following factors. (1) <jats:italic>Disease burden<\/jats:italic>: The incidence rate for the disease increased from 2003 to 2004; the northern and western regions of the country were the most affected. Sero\u2010prevalence data for children 1\u201315\u2003years old was 54% for the whole country, with differences per region and age. From May 1982 to September 2002, 210 patients were recruited with acute hepatic failure; HA was the aetiology in 61% of them. (2) <jats:italic>Cost\u2010effectiveness<\/jats:italic>: Compared with no vaccination, the one\u2010dose schedule would save US$15.3 millions, with regional variations. (3) <jats:italic>Vaccine features<\/jats:italic>: Immunization with one\u2010dose schedule HA vaccine confers good immunogenicity and effectiveness. (4) <jats:italic>Programmatic feasibility<\/jats:italic>: The National Immunizations Program has appropriate distribution system for vaccines, with adequate cold chain. (5) <jats:italic>Social acceptance and political compromise<\/jats:italic>: The population largely accepts HA vaccination and the national authorities should be committed to providing it regularly. The main global issue is that hepatitis A virus infection remains the most commonly reported vaccine\u2010preventable disease in many parts of the world despite the availability of vaccines.<\/jats:p>","DOI":"10.1111\/j.1365-2893.2008.01023.x","type":"journal-article","created":{"date-parts":[[2008,8,27]],"date-time":"2008-08-27T07:43:22Z","timestamp":1219823002000},"page":"16-21","source":"Crossref","is-referenced-by-count":10,"title":["The need for an evidence\u2010based decision\u2010making process with regard to control of hepatitis A"],"prefix":"10.1111","volume":"15","author":[{"given":"A.","family":"Gentile","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,8,27]]},"reference":[{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0676.1988.tb00967.x"},{"key":"e_1_2_12_3_2","first-page":"790","volume-title":"Infection Diseases","author":"Stapleton JT","year":"1994"},{"key":"e_1_2_12_4_2","first-page":"38","article-title":"Hepatitis A vaccines","volume":"5","author":"WHO","year":"2000","journal-title":"Wkly Epidemiol Rec"},{"key":"e_1_2_12_5_2","volume-title":"Bolet\u00edn Oficial de la Rep\u00fablica Argentina. 113(30677)","author":"Argentina, Ministerio de Salud y Ambiente. 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