{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T05:39:37Z","timestamp":1702618777199},"reference-count":26,"publisher":"Wiley","issue":"s2","license":[{"start":{"date-parts":[[2008,8,27]],"date-time":"2008-08-27T00:00:00Z","timestamp":1219795200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:p><jats:bold>Summary.\u2002<\/jats:bold> We retrospectively analysed 33 children and adolescents who had been hospitalized in a liver transplant unit within the previous 10\u2003years for acute liver failure (ALF). The patients\u2019 age varied between 2\u2003months and 15\u2003years of age (median 6.2\u2003\u00b1\u20035.3), and 21 (63%) were male. Thirteen patients (39%) were immunoglobulin\u2010M anti\u2010hepatitis A virus (HAV) sero\u2010positive. Eleven cases (33%) had an undetermined aetiology. The 13 children with HAV ALF were between 17\u2003months and 15.6\u2003years of age (median 5.8\u2003\u00b1\u20034.6) and eight were male (61.5%). All were on a list for urgent liver transplant. Of these, five (38%) died while waiting for a liver. Only one patient recovered spontaneously. Seven patients received a liver transplant; three died in the immediate postoperative period and one died 45\u2003days after transplant. Three children are alive 1, 2 and 5\u2003years after transplant. We conclude that HAV was the most frequent cause of ALF, which had high mortality even when a liver transplant was possible. 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