{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T10:04:10Z","timestamp":1784541850877,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"s2","license":[{"start":{"date-parts":[[2008,8,27]],"date-time":"2008-08-27T00:00:00Z","timestamp":1219795200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:p><jats:bold>Summary.\u2002<\/jats:bold> Hepatitis A is a worldwide vaccine\u2010preventable infection. Recommendation of vaccination depends on the endemicity of the disease. The World Health Organization recommends universal hepatitis A vaccination in intermediate areas; however, there is no need of mass vaccination in high and low endemicity regions. Therefore, most of the countries are using a vaccination policy according to the endemicity characteristic representing the whole of the country. The endemicity of this infection varies due to sanitary and hygiene conditions and socioeconomic differences among the countries and in various regions of the same country. A sample of 1173 persons between the age of 0 and 91\u2003years from nine randomly selected medical centres from five different geographical centres of Turkey were tested for the level of anti\u2010hepatitis A virus (anti\u2010HAV) immunoglobulin\u2010G antibodies using an enzyme\u2010linked immunosorbent assay. The overall prevalence of anti\u2010HAV antibodies was 64.4% (1142\/1173). While the rate of sero\u2010positivity was over 80% in the 5\u20139 age group and more than 90% after 14\u2003years of age in south\u2010eastern and eastern regions, it was lower than 50% at the age of 5\u20139\u2003years in central and western regions and remains under 80% in those areas. We conclude that the differences observed in HAV sero\u2010positivity among various geographical regions in Turkey support a universal HAV immunization policy for children currently living in regions of intermediate endemicity.<\/jats:p>","DOI":"10.1111\/j.1365-2893.2008.01034.x","type":"journal-article","created":{"date-parts":[[2008,8,27]],"date-time":"2008-08-27T07:43:22Z","timestamp":1219823002000},"page":"69-72","source":"Crossref","is-referenced-by-count":29,"title":["Differences in hepatitis A seroprevalence among geographical regions in Turkey: a need for regional vaccination 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