{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T15:32:48Z","timestamp":1759159968629},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2011,1,18]],"date-time":"2011-01-18T00:00:00Z","timestamp":1295308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:p><jats:bold>Summary.\u2002<\/jats:bold> Whether HIV controllers, patients who spontaneously control HIV viraemia, are able to control hepatitis C virus (HCV) infection, in terms of spontaneous clearance or lower HCV replication, is not well understood. To assess to what extent Caucasian HIV controllers are able to control HCV replication and potential associated factors, plasma HIV\u20101 and HCV RNA levels, anti\u2010HCV antibodies, HCV genotype and human leucocyte antigens (HLA) typing were determined in samples from 75 HIV controllers (33 viraemic controllers, &lt;1000 HIV\u20101 RNA\u2003copies\/mL, and 42 elite controllers, &lt;40 HIV\u20101 RNA\u2003copies\/mL) and compared with 261 HIV\u2010infected noncontrollers. We did not find differences in the HCV spontaneous clearance rates between groups. However, we interestingly found a lower HCV viral load in HIV controllers, alongside a different distribution of HCV genotypes in relation to the comparison group. In addition, HLA\u2010B57 was associated with a lower HCV viral load in the control group and HIV controllers, and conversely, HLA\u2010B35 with higher HCV viral load in HIV controllers. The subrepresentation of HCV genotype 1 and the overrepresentation of HLA\u2010B57 only partly explained the lower HCV viral load found in HIV controllers. In fact, HIV controller status was independently associated with lower HCV viral load, together with HCV genotype non\u20101, the presence of HLA\u2010B57 and absence of HLA\u2010B35. Caucasian HIV controllers are able to better control HCV replication, in terms of lower HCV viral load levels. These findings support the idea that some common host mechanisms are involved in the defence against these two persistent infections.<\/jats:p>","DOI":"10.1111\/j.1365-2893.2010.01431.x","type":"journal-article","created":{"date-parts":[[2011,1,19]],"date-time":"2011-01-19T01:59:26Z","timestamp":1295402366000},"source":"Crossref","is-referenced-by-count":23,"title":["Hepatitis C virus replication in Caucasian HIV controllers"],"prefix":"10.1111","volume":"18","author":[{"given":"E.","family":"Ruiz\u2010Mateos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Machmach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. C.","family":"Romero\u2010Sanchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Ferrando\u2010Martinez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Viciana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Del Val","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. A.","family":"Mu\u00f1oz\u2010Fernandez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Genebat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Leal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf of the Cohort of the Spanish AIDS Research Network (CoRIS)","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,1,18]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/433188"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.08.010"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(97)80001-3"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32833a2a32"},{"key":"e_1_2_9_6_2","first-page":"37","article-title":"HLA\u2010B35 is associated with accelerated progression to AIDS","volume":"5","author":"Itescu S","year":"1992","journal-title":"J Acquir Immune Defic Syndr"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02128-08"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1086\/318539"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23101"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/175.1.164"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1086\/426513"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.050567397"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08997"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01471-08"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20848"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.10.4792-4797.2002"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23515"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23624"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.447"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.449"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08463"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21376"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0030492"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/174.4.690"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.037788"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.1996.tb00104.x"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1086\/342388"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200203290-00006"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200205240-00004"}],"container-title":["Journal of Viral Hepatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2893.2010.01431.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2893.2010.01431.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2893.2010.01431.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/j.1365-2893.2010.01431.x","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2893.2010.01431.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T14:16:46Z","timestamp":1693837006000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2893.2010.01431.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1,18]]},"references-count":28,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["10.1111\/j.1365-2893.2010.01431.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2893.2010.01431.x","archive":["Portico"],"relation":{},"ISSN":["1352-0504","1365-2893"],"issn-type":[{"type":"print","value":"1352-0504"},{"type":"electronic","value":"1365-2893"}],"subject":[],"published":{"date-parts":[[2011,1,18]]}}}