{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T01:31:17Z","timestamp":1720143077305},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,9,14]],"date-time":"2011-09-14T00:00:00Z","timestamp":1315958400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:p><jats:bold>Summary.\u2002<\/jats:bold> Obesity and insulin resistance have been reported as negative predictors for sustained virological response (SVR) in hepatitis C virus (HCV) genotype 1 infected patients treated with pegylated interferon\u2010\u03b1 plus ribavirin. They are also known to affect serum levels of several cytokines including adipocytokines. But the association between these cytokines and treatment outcome has not been fully elucidated. We examined pretreatment serum levels of 14 cytokines among 190 patients who were treated with pegylated interferon\u2010\u03b1\u20102b plus ribavirin for chronic HCV\u20101b infection with high viral load (\u22655\u2003log\u2003IU\/mL) and analyzed their contribution to treatment response. Plasminogen activator inhibitor\u20101 (PAI\u20101), vascular endothelial growth factor, and 11 clinical factors showed significant association with SVR in univariate logistic regression analysis. Four significant factors in multivariate analysis; serum PAI\u20101 (odds ratio [OR]\u2003=\u200315.42), body mass index (OR\u2003=\u20034.56), rs8099917 (OR\u2003=\u20034.95) and fibrosis stage (OR\u2003=\u20035.18) were identified as independent predictors. We constructed a simple and minimally invasive prediction score for SVR based on the presence of these factors except for fibrosis stage. The accuracy of this score was 73%, and was confirmed using an independent validation cohort consisting of 31 patients (68%). The strongest correlation was between PAI\u20101 level and platelet count (<jats:italic>r<\/jats:italic>\u2003=\u20030.38, <jats:italic>P<\/jats:italic>\u2003=\u20031.8\u2003\u00d7\u200310<jats:sup>\u22127<\/jats:sup>), and PAI\u20101 level was inversely correlated with fibrosis stage. Serum PAI\u20101 is a novel predictor for the response to combination therapy against chronic HCV\u20101b infection and may be associated with liver fibrosis.<\/jats:p>","DOI":"10.1111\/j.1365-2893.2011.01516.x","type":"journal-article","created":{"date-parts":[[2011,9,14]],"date-time":"2011-09-14T07:12:04Z","timestamp":1315984324000},"source":"Crossref","is-referenced-by-count":4,"title":["Serum PAI\u20101 is a novel predictor for response to pegylated interferon\u2010\u03b1\u20102b plus ribavirin therapy in chronic hepatitis C virus infection"],"prefix":"10.1111","volume":"19","author":[{"given":"D.","family":"Miki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Ohishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Ochi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. 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