{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:22:44Z","timestamp":1761895364234},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,10,30]],"date-time":"2011-10-30T00:00:00Z","timestamp":1319932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:p><jats:bold>Summary.\u2002<\/jats:bold> We evaluated whether quantitative measurements of liver fibrosis with recently developed diagnostics outperform histological staging in detecting natural or interferon\u2010induced changes. We compared Metavir staging, morphometry (area and fractal dimension) and six blood tests in 157 patients with chronic hepatitis C from two trials testing maintenance interferon for 96\u2003weeks. Paired liver biopsies and blood tests were available for 101 patients, and there was a significant improvement in Metavir activity and a significant increase in blood tests reflecting fibrosis quantity in patients treated with interferon when compared with controls \u2013 all per cent changes in histological fibrosis measures were significantly increased in F1 <jats:italic>vs<\/jats:italic> F2\u20134 stages only in the interferon group. For the whole population studied between weeks 0 and 96, there was significant progression only in the area of fibrosis (AOF) (<jats:italic>P<\/jats:italic>\u2003=\u20030.026), FibroMeter (<jats:italic>P<\/jats:italic>\u2003=\u20030.020) and CirrhoMeter (<jats:italic>P<\/jats:italic>\u2003=\u20030.003). With regards to dynamic reproducibility, agreement was good (<jats:italic>r<\/jats:italic><jats:sub>ic<\/jats:sub>\u2003\u2265\u20030.72) only for Metavir fibrosis score, FibroMeter and CirrhoMeter. The per cent change in AOF was significantly higher than that of fractal dimension (<jats:italic>P<\/jats:italic>\u2003=\u20030.003) or Metavir fibrosis score (<jats:italic>P<\/jats:italic>\u2003=\u20030.015). CirrhoMeter was the only blood test with a change significantly higher than that of AOF (<jats:italic>P<\/jats:italic>\u2003=\u20030.039). AOF and two blood tests, reflecting fibrosis quantity, have high sensitivity and\/or reproducibility permitting the detection of a small progression in liver fibrosis over two years. A blood test reflecting fibrosis quantity is more sensitive and reproducible than morphometry. The study also shows that maintenance interferon does not improve fibrosis, whatever its stage.<\/jats:p>","DOI":"10.1111\/j.1365-2893.2011.01531.x","type":"journal-article","created":{"date-parts":[[2011,10,31]],"date-time":"2011-10-31T01:07:15Z","timestamp":1320023235000},"source":"Crossref","is-referenced-by-count":7,"title":["Fibrosis progression under maintenance interferon in hepatitis C is better detected by blood test than liver morphometry"],"prefix":"10.1111","volume":"19","author":[{"given":"P.","family":"Cal\u00e8s","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. P.","family":"Zarski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Marc Chapplain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Bertrais","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Sturm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Michelet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Babany","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Chaigneau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Eddine Charaf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"multicentric groups (Fibrosys, ANRS HC 12, Fibrostop)","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,10,30]]},"reference":[{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(02)00387-2"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0707615"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(98)80318-8"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.35533"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21595"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23211"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2010.02265.x"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.3851\/IMP1570"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.207423"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20935"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e32830cebd7"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2010.08.010"},{"key":"e_1_2_10_14_2","unstructured":"ChapplainJ BellissantE MolinaJet\u00a0al.Evaluation of the efficacy of pegylated interferon on liver fibrosis in co\u2010infected patient with HIV and hepatitis C.ICAAC: Boston MA; September 12\u201315 2010; Abst. V\u20101783."},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840200104"},{"issue":"6","key":"e_1_2_10_16_2","first-page":"312","article-title":"Fractal dimension rectified meter for quantification of liver fibrosis and other irregular microscopic objects","volume":"25","author":"Dioguardi N","year":"2003","journal-title":"Anal Quant Cytol Histol"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2005.048389"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2008.01789.x"},{"key":"e_1_2_10_19_2","first-page":"273","volume-title":"Statistical Methods in Medical Research","author":"Armitage P","year":"1994"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20535"},{"issue":"2","key":"e_1_2_10_21_2","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1177\/135965350901400205","article-title":"Effect of antiviral treatment on serum markers of liver fibrosis in HIV\u2010hepatitis C virus\u2010coinfected patients: the Fibrovic 2 Study \u2013 ANRS HC02","volume":"14","author":"Halfon P","year":"2009","journal-title":"Antivir Ther"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32830e6d51"},{"key":"e_1_2_10_23_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1997.v113.pm9322499"},{"key":"e_1_2_10_24_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1272836"},{"key":"e_1_2_10_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hep.2003.09.022"},{"key":"e_1_2_10_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2007.08.009"},{"key":"e_1_2_10_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2008.06.020"},{"key":"e_1_2_10_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.05.035"},{"key":"e_1_2_10_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.05.024"},{"key":"e_1_2_10_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24169"}],"container-title":["Journal of Viral Hepatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2893.2011.01531.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2893.2011.01531.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T09:09:00Z","timestamp":1698656940000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2893.2011.01531.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,30]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["10.1111\/j.1365-2893.2011.01531.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2893.2011.01531.x","archive":["Portico"],"relation":{},"ISSN":["1352-0504","1365-2893"],"issn-type":[{"type":"print","value":"1352-0504"},{"type":"electronic","value":"1365-2893"}],"subject":[],"published":{"date-parts":[[2011,10,30]]}}}