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Clinical management of graft hepatitis can be challenging as in addition to rejection and HCV\u2010induced hepatitis various other factors might be involved including toxic liver injury, steatohepatitis, ischaemic bile duct lesions or infections with other pathogens. Treatment options are often contradictory for different causes of graft hepatitis, and the role of distinct immunosuppressive drugs has been discussed controversially. Corticosteroids increase the infectivity of HCV by altering expression levels of entry factors and other immunosuppressive agents may have diverse effects on HCV replication and fibrosis progression. Interferon alpha\u2010therapy of hepatitis C shows limited efficacy and tolerability in liver transplant recipients and may also cause rejection. In this review we summarize the current knowledge on mechanisms of liver injury in post\u2010transplant hepatitis C, discuss the pros and cons of immunosuppressive agents in this specific setting and describe potential novel approaches to prevent HCV reinfection.<\/jats:p>","DOI":"10.1111\/j.1365-2893.2011.01548.x","type":"journal-article","created":{"date-parts":[[2011,11,8]],"date-time":"2011-11-08T03:24:41Z","timestamp":1320722681000},"page":"1-8","source":"Crossref","is-referenced-by-count":45,"title":["Immunosuppression, liver injury and post\u2010transplant HCV 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