{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T09:55:45Z","timestamp":1780998945779,"version":"3.54.1"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,2,22]],"date-time":"2012-02-22T00:00:00Z","timestamp":1329868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:p><jats:bold>Summary.\u2002<\/jats:bold> Low\u2010density lipoprotein cholesterol (LDL\u2010C) levels and interleukin 28B (<jats:italic>IL28B<\/jats:italic>) polymorphism are associated with sustained viral response (SVR) to peginterferon\/ribavirin (pegIFN\/RBV) for chronic hepatitis C (CHC) infection. <jats:italic>IL28B<\/jats:italic> has been linked with LDL\u2010C levels using a candidate gene approach, but it is not known whether other genetic variants are associated with LDL\u2010C, nor how these factors definitively affect SVR. We assessed genetic predictors of serum lipid and triglyceride levels in 1604 patients with genotype 1 (G1) chronic hepatitis C virus (HCV) infection by genome\u2010wide association study and developed multivariable predictive models of SVR. <jats:italic>IL28B<\/jats:italic> polymorphisms were the only common genetic variants associated with pretreatment LDL\u2010C level in Caucasians (rs12980275, <jats:italic>P<\/jats:italic>\u2003=\u20034.7\u2003\u00d7\u200310<jats:sup>\u221217<\/jats:sup>, poor response <jats:italic>IL28B<\/jats:italic> variants associated with lower LDL\u2010C). The association was dependent on HCV infection, <jats:italic>IL28B<\/jats:italic> genotype was no longer associated with LDL\u2010C in SVR patients after treatment, while the association remained significant in non\u2010SVR patients (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001). LDL\u2010C was significantly associated with SVR for heterozygous <jats:italic>IL28B<\/jats:italic> genotype patients (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001) but not for homozygous genotypes. SVR modelling suggested that <jats:italic>IL28B<\/jats:italic> heterozygotes with LDL\u2010C\u2003&gt;\u2003130\u2003mg\/dL and HCV RNA \u2264600 000\u2003IU\/mL may anticipate cure rates &gt;80%, while the absence of these two criteria was associated with an SVR rate of &lt;35%. <jats:italic>IL28B<\/jats:italic> polymorphisms are the only common genetic variants associated with pretreatment LDL\u2010C in G1\u2010HCV. LDL\u2010C remains significantly associated with SVR for heterozygous <jats:italic>IL28B<\/jats:italic> genotype patients, where LDL\u2010C and HCV RNA burden may identify those patients with high or low likelihood of cure with pegIFN\/RBV therapy.<\/jats:p>","DOI":"10.1111\/j.1365-2893.2011.01553.x","type":"journal-article","created":{"date-parts":[[2012,2,22]],"date-time":"2012-02-22T23:56:25Z","timestamp":1329954985000},"page":"332-340","source":"Crossref","is-referenced-by-count":28,"title":["Interleukin 28B polymorphisms are the only common genetic variants associated with low\u2010density lipoprotein cholesterol (LDL\u2010C) in genotype\u20101 chronic hepatitis C and determine the association between LDL\u2010C and treatment response"],"prefix":"10.1111","volume":"19","author":[{"given":"P. J.","family":"Clark","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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