{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T21:10:42Z","timestamp":1771881042275,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,12,19]],"date-time":"2011-12-19T00:00:00Z","timestamp":1324252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p><jats:bold>Summary.\u2002<\/jats:bold> Long\u2010term safety of treatment with hepatitis B virus (HBV) polymerase inhibitors is a concern. Adefovir dipivoxil (ADV) therapy has previously been associated with impairment of renal function. Limited data are available on the safety of combination therapy with nucleos(t)ide analogues and interferon alfa (IFN\u03b1). The aim of this analysis was to assess the renal function during combination therapy with peginterferon alfa\u20102a (PegIFN\u03b1\u20102a) plus ADV <jats:italic>vs<\/jats:italic> either drug alone in patients with hepatitis B\/D co\u2010infection. We performed a retrospective analysis of renal function data of patients treated in the Hep\u2010Net\/International Delta Hepatitis Intervention Trial 1(HIDIT\u20101\u2010trial), a European multicenter study to investigate the efficacy of 48\u2003weeks of therapy with PegIFN\u03b1\u20102a+ADV <jats:italic>vs<\/jats:italic> either drug alone in 90 patients with chronic hepatitis B\/D co\u2010infection. Glomerular filtration rates (GFR) were calculated by Cockcroft\u2013Gault (CG), abbreviated Modification of Diet in Renal Disease (MDRD) study and Chronic Kidney Disease Epidemiology Collaboration (CKD\u2010EPI) equation. After 48\u2003weeks of therapy GFR values were significantly lower in patients receiving adefovir\u2010containing treatment <jats:italic>vs<\/jats:italic> PegIFN\u03b1\u20102a alone [mean difference 16.1\u2003mL\/min (CG) and 10.2\u2003mL\/min (MDRD), respectively, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05] while no differences were observed between patients receiving adefovir alone <jats:italic>vs<\/jats:italic> combination treatment. Twenty\u2010four weeks after treatment GFR values did not differ between treatment arms. A decrease in GFR \u226520% was observed more often in patients during adefovir\u2010containing treatment <jats:italic>vs<\/jats:italic> PegIFN\u03b1\u20102a alone (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05) which was confirmed by Kaplan\u2013Meier analysis. Adefovir\u2010containing but not PegIFN\u03b1\u20102a treatment was associated with a decrease in GFR values in about one\u2010fifth of patients. Combination treatment of PegIFN\u03b1\u20102a+ADV in chronic hepatitis B\/D co\u2010infection did not lead to any further impairment of kidney function.<\/jats:p>","DOI":"10.1111\/j.1365-2893.2011.01560.x","type":"journal-article","created":{"date-parts":[[2011,12,20]],"date-time":"2011-12-20T01:43:30Z","timestamp":1324345410000},"page":"387-395","source":"Crossref","is-referenced-by-count":8,"title":["Renal function during treatment with adefovir plus peginterferon alfa\u20102a <i>vs<\/i> either drug alone in hepatitis B\/D co\u2010infection"],"prefix":"10.1111","volume":"19","author":[{"given":"I.","family":"Mederacke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Yurdaydin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Gro\u00dfhennig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Erhardt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Cakaloglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Yalcin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Gurel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Zeuzem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Zachou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Chatzikyrkou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Bozkaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. 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