{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:26:12Z","timestamp":1760549172942},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2011,12,18]],"date-time":"2011-12-18T00:00:00Z","timestamp":1324166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:p><jats:bold>Summary.\u2002<\/jats:bold> Although hepatitis C (HCV) is associated with diabetes, few studies have examined pre\u2010diabetes in this population. We aimed to evaluate factors associated with pre\u2010diabetes in HCV\u2010infected patients, including direct measurement of insulin action. Ninety\u2010seven non\u2010cirrhotic, non\u2010diabetic and HCV\u2010infected patients underwent clinical evaluation and oral glucose tolerance testing (OGTT). Insulin sensitivity was measured directly by steady\u2010state plasma glucose (SSPG) concentration during insulin suppression test. Early phase and total insulin secretion were determined using OGTT. Rates of pre\u2010diabetes were as follows: 21% impaired fasting glucose (IFG), 7% impaired glucose tolerance (IGT) and 9% combined IFG\/IGT. Twelve percent of Caucasians, 50% of African Americans and 70% of Latinos had pre\u2010diabetes (<jats:italic>P<\/jats:italic>\u2003=\u20030.002). Patient characteristics among the glucose metabolism categories were similar except those with combined IFG\/IGT had a higher body mass index (BMI) <jats:italic>vs<\/jats:italic> normal glucose tolerance (NGT) (30 <jats:italic>vs<\/jats:italic> 26\u2003kg\/m<jats:sup>2<\/jats:sup>, <jats:italic>P<\/jats:italic>\u2003=\u20030.007) and lower LDL <jats:italic>vs<\/jats:italic> NGT and IGT (74, 104 and 112\u2003mg\/dL, respectively, <jats:italic>P<\/jats:italic>\u2003\u2264\u20030.01). On multivariable analysis, non\u2010Caucasian race (OR 23.1, <jats:italic>P<\/jats:italic>\u2003=\u20030.003), BMI (OR 3.4, <jats:italic>P<\/jats:italic>\u2003=\u20030.02) and greater liver inflammation (OR 7.9, <jats:italic>P<\/jats:italic>\u2003=\u20030.03) predicted IFG, whereas non\u2010Caucasian race (OR 14.8, <jats:italic>P<\/jats:italic>\u2003=\u20030.01) and SSPG (OR 1.1 per 10 units, <jats:italic>P<\/jats:italic>\u2003=\u20030.01) predicted IGT. Early and total insulin secretion adjusted for the degree of insulin resistance was decreased in pre\u2010diabetes compared with NGT (<jats:italic>P<\/jats:italic>\u2003=\u20030.01 and <jats:italic>P<\/jats:italic>\u2003=\u20030.02, respectively). Pre\u2010diabetes is highly prevalent among HCV\u2010infected patients, and in some instances, coincides with host responses to the virus. In most cases, however, factors that are associated with pre\u2010diabetes in HCV\u2010infected patients are similar to those observed in the non\u2010HCV population.<\/jats:p>","DOI":"10.1111\/j.1365-2893.2011.01568.x","type":"journal-article","created":{"date-parts":[[2011,12,19]],"date-time":"2011-12-19T05:10:50Z","timestamp":1324271450000},"page":"480-487","source":"Crossref","is-referenced-by-count":6,"title":["Assessment of factors associated with pre\u2010diabetes in HCV infection including direct and dynamic measurements of insulin action"],"prefix":"10.1111","volume":"19","author":[{"given":"N. A.","family":"Mukhtar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Ayala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. J.","family":"Maher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Khalili","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,12,18]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22759"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-133-8-200010170-00009"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-1957"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.164.19.2147"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2003.08.032"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.12.049"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/lt.20092"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-9920"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-S309"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.07.008"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23670"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.2007.S5"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199512000-00007"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-008-1148-z"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.1994.tb00273.x"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.21.4.518"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.6.1549"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2007.01626.x"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.050302"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63408-6"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hep.2003.09.012"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2003.11.056"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc05-2179"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.2337\/db05-1200"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.3.868"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.48.11.2197"}],"container-title":["Journal of Viral Hepatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2893.2011.01568.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2893.2011.01568.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T21:03:38Z","timestamp":1698699818000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2893.2011.01568.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,18]]},"references-count":26,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.1111\/j.1365-2893.2011.01568.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2893.2011.01568.x","archive":["Portico"],"relation":{},"ISSN":["1352-0504","1365-2893"],"issn-type":[{"value":"1352-0504","type":"print"},{"value":"1365-2893","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,18]]}}}