{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T20:38:04Z","timestamp":1759178284585},"reference-count":36,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,1,28]],"date-time":"2012-01-28T00:00:00Z","timestamp":1327708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:p><jats:bold>Summary.\u2002<\/jats:bold> Cyclooxygenase (<jats:italic>COX<\/jats:italic>)\u20102 is involved in inflammation, anti\u2010apoptosis and carcinogenesis. The \u20101195GG genotype of single nucleotide polymorphism (SNP) in <jats:italic>COX\u20102<\/jats:italic> promoter was associated with low platelet counts in patients with chronic hepatitis C. Polymorphism of patatin\u2010like phospholipase domain\u2010containing protein 3 (<jats:italic>PNPLA3<\/jats:italic>) gene (rs738409 C&gt;G) have been reported to be associated with cirrhosis, and the major genotype of SNPs near interleukin (IL)28B are related to viral clearance. The present study was designed to assess the contribution of these SNPs to disease progression in patients with chronic hepatitis C. The study enrolled 220 Japanese patients with chronic hepatitis C. Three SNPs, \u20101195 <jats:italic>COX\u20102<\/jats:italic>, <jats:italic>PNPLA3<\/jats:italic> and <jats:italic>IL28B<\/jats:italic> (rs8099917), were genotyped in order to analyze their association with hepatic fibrosis and inflammation. The \u20101195GG genotype in <jats:italic>COX\u20102<\/jats:italic> was associated with advanced fibrosis and higher levels of inflammation in the liver tissues. The major genotype of <jats:italic>IL28B<\/jats:italic> was also associated with advanced fibrosis, but the polymorphism of <jats:italic>PNPLA3<\/jats:italic> was neither associated with fibrosis nor inflammation. Multivariate analysis showed that \u20101195GG in <jats:italic>COX\u20102<\/jats:italic> is an independent factor associated with advanced fibrosis, while the major genotype of <jats:italic>IL28B<\/jats:italic> and HCV genotype 2 were other independent factors. In conclusion, the \u20101195GG genotype in <jats:italic>COX\u20102<\/jats:italic> is a genetic marker for liver disease progression, while the <jats:italic>PNPLA3<\/jats:italic> genotypes are not associated with disease progression in Japanese patients with chronic hepatitis C.<\/jats:p>","DOI":"10.1111\/j.1365-2893.2011.01580.x","type":"journal-article","created":{"date-parts":[[2012,1,28]],"date-time":"2012-01-28T07:31:56Z","timestamp":1327735916000},"page":"608-614","source":"Crossref","is-referenced-by-count":19,"title":["Genetic polymorphism in cyclooxygenase\u20102 promoter affects hepatic inflammation and fibrosis in patients with chronic hepatitis C"],"prefix":"10.1111","volume":"19","author":[{"given":"Miyuki","family":"Miyashita","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayoshi","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Sakaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Kajiwara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisako","family":"Nozawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazumasa","family":"Hiroishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariko","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromitsu","family":"Kumada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michio","family":"Imawari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,1,28]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(98)80339-5"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199506013322202"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2008.05475.x"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)07642-8"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-860869"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.4.574"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24350"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24123"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08309"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2003.04.002"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203286"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0045(20000101)42:1<73::AID-PROS9>3.0.CO;2-G"},{"key":"e_1_2_7_14_2","first-page":"519","article-title":"Increased expression of cyclooxygenase\u20102 protein in human gastric carcinoma","volume":"6","author":"Lim HY","year":"2000","journal-title":"Clin Cancer Res Official J Am Assoc Cancer Res"},{"key":"e_1_2_7_15_2","first-page":"3785","article-title":"Expression of cyclooxygenase\u20101 and \u20102 in human colorectal cancer","volume":"55","author":"Sano H","year":"1995","journal-title":"Cancer Res"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.038364"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-9-37"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2010.06.002"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2008.02986.x"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1872-034X.2010.00727.x"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840190629"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08463"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.05.003"},{"key":"e_1_2_7_24_2","first-page":"S41","article-title":"Hepatitis C virus genetic variability: clinical implications","volume":"89","author":"Brechot C","year":"1994","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.449"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510250336"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-011-9547-1"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24503"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir113"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.03.022"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24535"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0800651"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.36128"},{"key":"e_1_2_7_34_2","first-page":"1423","article-title":"Clinical significance of elevated alpha\u2010fetoprotein (AFP) in chronic hepatitis C without hepatocellular carcinoma","volume":"55","author":"Chen CH","year":"2008","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24608"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2009.02061.x"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.202267"}],"container-title":["Journal of Viral Hepatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2893.2011.01580.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2893.2011.01580.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T00:53:42Z","timestamp":1698627222000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2893.2011.01580.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,28]]},"references-count":36,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["10.1111\/j.1365-2893.2011.01580.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2893.2011.01580.x","archive":["Portico"],"relation":{},"ISSN":["1352-0504","1365-2893"],"issn-type":[{"value":"1352-0504","type":"print"},{"value":"1365-2893","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,28]]}}}