{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T06:26:51Z","timestamp":1789712811617,"version":"4.0.1"},"reference-count":38,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2012,3,15]],"date-time":"2012-03-15T00:00:00Z","timestamp":1331769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:p><jats:bold>Summary.\u2002<\/jats:bold>The role of exposure to antiretrovirals (ARV) and serum matrix metalloproteases (MMPs) on liver fibrosis (LF) progression in human immunodeficiency virus (HIV) mono or HIV\u2013 hepatitis C virus (HCV) coinfection is unclear. Thus, 213 Caucasian adult HIV\u2010infected patients were studied, 111 of whom had HCV\u2010coinfection and 68 were HCV\u2010monoinfected. Patients with ethanol consumption &gt;50\u2003g\/day, hepatitis B coinfection, non\u2010infective liver diseases or HAART adherence &lt;75% were excluded. LF was assessed by transient elastometry (TE, Fibroscan). Serum levels of MMPs (MMP \u20101,\u20102,\u20103,\u20108,\u20109,\u201010 and \u201013) and their tissue inhibitors (TIMP\u20101,\u20102 and \u20104) were measured by ELISA microarrays. Associations with LF were statistically analysed. Protease inhibitors, usually administered to patients with advanced LF were excluded from the analysis. Increased LF was significantly associated with d4T (<jats:italic>P<\/jats:italic>\u2003=\u20030.006) and didanosine (ddI) use (<jats:italic>P<\/jats:italic>\u2003=\u20030.007), months on d4T (<jats:italic>P<\/jats:italic>\u2003=\u20030.001) and on ARV (<jats:italic>P<\/jats:italic>\u2003=\u20030.025), duration of HIV (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001) and HCV infections (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001), higher HIV (<jats:italic>P<\/jats:italic>\u2003=\u20030.03) and HCV loads (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001), presence of lipodystrophy (<jats:italic>P<\/jats:italic>\u2003=\u20030.02), male gender (<jats:italic>P<\/jats:italic>\u2003=\u20030.02), older age (<jats:italic>P<\/jats:italic>\u2003=\u20030.04), low nadir (<jats:italic>P<\/jats:italic>\u2003=\u20030.02) and current CD4<jats:sup>+<\/jats:sup>T\u2010cells (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001), low gain of CD4<jats:sup>+<\/jats:sup>T\u2010cells after HAART (<jats:italic>P<\/jats:italic>\u2003=\u20030.01) and higher MMP\u20102 (<jats:italic>P<\/jats:italic>\u2003=\u20030.02) and TIMP\u20102 serum levels (<jats:italic>P<\/jats:italic>\u2003=\u20030.02). By logistic regression the only variables significantly associated with increased LF were: use of ddI (OR 8.77, 95% CI: 2.36\u201332.26;<jats:italic>P<\/jats:italic>\u2003=\u20030.005), male gender (OR 7.75, 95% CI: 2.33\u201325.64,<jats:italic>P<\/jats:italic>\u2003=\u20030.0008), HCV viral load (in log) (OR 3.53, 95% CI: 2.16\u20135.77;<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001) and age (in years) (OR 1.21, 95% CI: 1.09\u20131.34,<jats:italic>P<\/jats:italic>\u2003=\u20030.0003). We conclude that only higher HCV viral load, older age, male gender, and use of ddI associated independently with increased LF in our study.<\/jats:p>","DOI":"10.1111\/j.1365-2893.2012.01596.x","type":"journal-article","created":{"date-parts":[[2012,3,16]],"date-time":"2012-03-16T02:17:55Z","timestamp":1331864275000},"page":"685-693","source":"Crossref","is-referenced-by-count":26,"title":["Didanosine (ddI) associates with increased liver fibrosis in adult HIV\u2013HCV coinfected patients"],"prefix":"10.1111","volume":"19","author":[{"given":"T.","family":"Su\u00e1rez\u2010Zarracina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Valle\u2010Garay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Collazos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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