{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T22:52:44Z","timestamp":1715986364013},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,7,25]],"date-time":"2012-07-25T00:00:00Z","timestamp":1343174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:p><jats:bold>Summary.\u2002<\/jats:bold> Genetic factors can influence the outcome of antiviral therapy in chronic hepatitis C (HCV). We evaluated the role of interleukin\u201028B single nucleotide polymorphisms (SNPs) and inosine triphosphatase (ITPA) gene variants in HCV cirrhosis treated with Peg\u2010Interferon and ribavirin. A prospective cohort of 233 patients with compensated cirrhosis received 1\u20131.5\u2003\u03bcg\/kg\/week of Peg\u2010Interferon alpha\u20102b plus 1000\u20131200\u2003mg\/day of RBV for 48\u2003weeks. A sustained virologic response (SVR) was achieved in 27% of patients. On multivariate logistic analysis, the absence of oesophageal varices (OR 3.64 CI 95% 1.27\u201310.44 <jats:italic>P<\/jats:italic>\u2003=\u20030.016), infection with genotype 2 or 3 (OR 4.06, CI 95% 1.08\u201315.26, <jats:italic>P<\/jats:italic>\u2003=\u20030.038), C\/C alleles of rs12979860 SNP (OR 7.04, CI 95% 2.40\u201320.72, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001) and rapid virologic response (RVR) (OR 78.29, CI 95% 16.07\u2013381.29, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001) were independently associated with SVR. Patients who experienced post\u2010treatment relapse received lower total doses of Peg\u2010Interferon (52.0\u2003\u00b1\u200315.8\u2003\u03bcg\/kg <jats:italic>vs<\/jats:italic> 65.7\u2003\u00b1\u200313.3\u2003\u03bcg\/kg, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001) and lower total dose of RBV (3829\u2003\u00b1\u20031210\u2003mg <jats:italic>vs<\/jats:italic> 4709\u2003\u00b1\u2003954\u2003mg, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001) than patients who achieved an SVR. ITPA variants predictive of high ITPase activity were associated with reduction of haemoglobin \u22653\u2003g\/dL in the first 4\u2003weeks (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001), and with reduction of haemoglobin &lt;10\u2003g\/dL (<jats:italic>P<\/jats:italic>\u2003=\u20030.03) on treatment. In conclusion, combination therapy with Peg\u2010Interferon and RBV in patients with HCV cirrhosis must be guided by virus genotype, severity of portal hypertension, favourable IL\u201028B polymorphisms and ITPA variants, and RVR on treatment.<\/jats:p>","DOI":"10.1111\/j.1365-2893.2012.01637.x","type":"journal-article","created":{"date-parts":[[2012,7,25]],"date-time":"2012-07-25T09:49:17Z","timestamp":1343209757000},"page":"113-121","source":"Crossref","is-referenced-by-count":13,"title":["Role of IL\u201028B and inosine triphosphatase polymorphisms in efficacy and safety of Peg\u2010Interferon and ribavirin in chronic hepatitis C compensated cirrhosis with and without oesophageal varices"],"prefix":"10.1111","volume":"20","author":[{"given":"V.","family":"Di Marco","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Calvaruso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Grimaudo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Ferraro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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