{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:06:30Z","timestamp":1761919590764},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,7,13]],"date-time":"2012-07-13T00:00:00Z","timestamp":1342137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:p><jats:bold>Summary.\u2002<\/jats:bold> Hepatitis C virus (HCV) subtype 1b, which infects approximately 70% of Japanese carriers, is likely to be more eradicable by a telaprevir regimen than subtype 1a because of the higher genetic barrier of Val<jats:sup>36<\/jats:sup> and Arg<jats:sup>155<\/jats:sup> substitutions. The aims of this exploratory study were to evaluate the virological response and safety of 24\u2010week oral administration of telaprevir alone in chronic HCV subtype 1b infection. Fifteen treatment\u2010na\u00efve patients were treated with telaprevir 750\u2003mg every 8\u2003h for 24\u2003weeks. All patients were Japanese whose median age was 58.0\u2003years (range: 45\u201368), and six patients (40%) were men. Median baseline HCV RNA level was 6.80\u2003log<jats:sub>10<\/jats:sub>\u2003IU\/mL (range: 3.55\u20137.10). The HCV RNA levels decreased to undetectable in five patients (33%) within 8\u2003weeks. Three patients (20%) with negative HCV RNA by Week 4 achieved end of treatment response. One patient (7%) who achieved sustained virological response had a low baseline viraemia of 3.55\u2003log<jats:sub>10<\/jats:sub>\u2003IU\/mL. Most of the adverse events including anaemia and skin disorders were mild to moderate. Developed variants were T54A and A156V\/T\/F\/Y with or without secondary substitutions rather than V36M\u2003\u00b1\u2003R155K. Telaprevir alone for 24\u2003weeks in Japanese patients with HCV subtype 1b resulted in an sustained viral response rate of 7% (1\/15) and was well tolerated for 24\u2003weeks. These results will support the implementation of further studies on oral combination of telaprevir with other direct\u2010acting antiviral agents in patients infected with HCV subtype 1b.<\/jats:p>","DOI":"10.1111\/j.1365-2893.2012.01640.x","type":"journal-article","created":{"date-parts":[[2012,7,13]],"date-time":"2012-07-13T20:20:00Z","timestamp":1342210800000},"page":"167-173","source":"Crossref","is-referenced-by-count":11,"title":["Virological response and safety of 24\u2010week telaprevir alone in Japanese patients infected with hepatitis C virus subtype 1b"],"prefix":"10.1111","volume":"20","author":[{"given":"J.","family":"Toyota","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Ozeki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Karino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Asahina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Izumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Kawakami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Chayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Kamiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Aoki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Kumada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,7,13]]},"reference":[{"key":"e_1_2_7_2_2","unstructured":"World Health Organization.Fact sheet No.164 June 2011 Hepatitis C. 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