{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:19:59Z","timestamp":1790698799731,"version":"4.1.0"},"reference-count":69,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,8,2]],"date-time":"2006-08-02T00:00:00Z","timestamp":1154476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["resjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Medical Vet Entomology"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:p>\n                    <jats:bold>Abstract<\/jats:bold>\n                    The principles of meta\u2010analysis developed in a previous study were extended to investigate the process of\n                    <jats:italic>Wuchereria bancrofti<\/jats:italic>\n                    (Cobbold) (Filarioidea: Onchocercidae) infection in mosquito (Diptera: Culicidae) hosts, focusing specifically on the functional forms and strength of density dependence in the development of ingested microfilariae (mf) to infective (third instar) larvae (L3). Mathematical models describing observed mf\u2212L3 functional responses for each of the major three parasite\u2010transmitting vector genera,\n                    <jats:italic>Aedes, Culex<\/jats:italic>\n                    and\n                    <jats:italic>Anopheles<\/jats:italic>\n                    mosquitoes, were fitted to paired mf\u2212L3 data collated from all available studies in the published literature. Model parameters were estimated and compared by deriving and applying a data synthetic framework, based on applying a non\u2010linear weighted regression model for fitting mathematical models to multistudy data. The results confirm previous findings of the existence of significant between\u2010genera differences in the mf\u2212L3 development relationship, particularly with regard to the occurrence of limitation in\n                    <jats:italic>Culex<\/jats:italic>\n                    mosquitoes and facilitation in\n                    <jats:italic>Aedes<\/jats:italic>\n                    and\n                    <jats:italic>Anopheles<\/jats:italic>\n                    mosquitoes. New and unexpected findings regarding L3 development from ingested mf were discovered as follows: (1) for\n                    <jats:italic>Culex<\/jats:italic>\n                    , overcompensation in L3 development at higher intensities of mf (or a peaked mf\u2212L3 functional response) was detected; (2) for\n                    <jats:italic>Aedes<\/jats:italic>\n                    mosquitoes, facilitation (with an apparent asymptotic constraint on L3 development at high mf densities) was shown to be the major process governing L3 development, and (3) for\n                    <jats:italic>Anopheles,<\/jats:italic>\n                    a stronger facilitation type of response with no apparent saturation in L3 development appears to govern L3 output from ingested mf. These results yield major new insights regarding filarial vector infection dynamics and their potential impacts on parasite control, and demonstrate the efficacy of employing a data synthetic approach to reveal and estimate parasitic infection processes in host populations.\n                  <\/jats:p>","DOI":"10.1111\/j.1365-2915.2006.00629.x","type":"journal-article","created":{"date-parts":[[2006,8,2]],"date-time":"2006-08-02T19:07:58Z","timestamp":1154545678000},"page":"261-272","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Transmission dynamics of lymphatic filariasis: vector\u2010specific density dependence in the development of\n                    <i>Wuchereria bancrofti<\/i>\n                    infective larvae in mosquitoes"],"prefix":"10.1111","volume":"20","author":[{"given":"L. C.","family":"SNOW","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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