{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:55:25Z","timestamp":1787014525980,"version":"build-2736575974"},"reference-count":56,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,10,19]],"date-time":"2011-10-19T00:00:00Z","timestamp":1318982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["resjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Medical Vet Entomology"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p>\n                    In the laboratory,\n                    <jats:italic>Amblyomma cajennense<\/jats:italic>\n                    (Acari: Ixodidae) (Fabricius) larvae, nymphs and adults were exposed to\n                    <jats:italic>Rickettsia rickettsii<\/jats:italic>\n                    by feeding on needle\u2010inoculated animals, and thereafter reared on uninfected guinea pigs or rabbits. Regardless of the tick stage that acquired the infection, subsequent tick stages were shown to be infected (confirming transstadial and transovarial transmissions) and were able to transmit\n                    <jats:italic>R. rickettsii<\/jats:italic>\n                    to uninfected animals, as demonstrated by serological and molecular analyses. However, the larval, nymphal and adult stages of\n                    <jats:italic>A. cajennense<\/jats:italic>\n                    were shown to be partially refractory to\n                    <jats:italic>R. rickettsii<\/jats:italic>\n                    infection, as in all cases, only part of the ticks became infected by this agent, after being exposed to rickettsemic animals. In addition, less than 50% of the infected engorged females transmitted rickettsiae transovarially, and when they did so, only part of the offspring became infected, indicating that vertical transmission alone is not enough to maintain\n                    <jats:italic>R. rickettsii<\/jats:italic>\n                    in\n                    <jats:italic>A. cajennense<\/jats:italic>\n                    for multiple generations. Finally, the\n                    <jats:italic>R. rickettsii<\/jats:italic>\n                    \u2010infected tick groups had lower reproductive performance than the uninfected control group. Our results indicate that\n                    <jats:italic>A. cajennense<\/jats:italic>\n                    have a low efficiency to maintain\n                    <jats:italic>R. rickettsii<\/jats:italic>\n                    for successive generations, as\n                    <jats:italic>R. rickettsii<\/jats:italic>\n                    \u2010infection rates should decline drastically throughout the successive tick generations.\n                  <\/jats:p>","DOI":"10.1111\/j.1365-2915.2011.00982.x","type":"journal-article","created":{"date-parts":[[2011,10,19]],"date-time":"2011-10-19T03:33:02Z","timestamp":1318995182000},"page":"139-151","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":87,"title":["Experimental infection of the tick\n                    <i>Amblyomma cajennense<\/i>\n                    , Cayenne tick, with\n                    <i>Rickettsia rickettsii<\/i>\n                    , the agent of Rocky Mountain spotted fever"],"prefix":"10.1111","volume":"26","author":[{"given":"J. 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