{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:00:03Z","timestamp":1791180003109,"version":"4.1.0"},"reference-count":59,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,11,23]],"date-time":"2011-11-23T00:00:00Z","timestamp":1322006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["resjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Medical Vet Entomology"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:p>\n                    We report key physiological traits that link larval nutritional experience to adult immune status in the yellow fever mosquito\n                    <jats:italic>Aedes aegypti<\/jats:italic>\n                    L. (\n                    <jats:italic>Stegomyia aegypti<\/jats:italic>\n                    ) (Diptera: Culicidae). Many lines of defence make up the innate immune system of mosquitoes. Among defences, the epithelium\u2010lined midgut is the first barrier, circulating haemocytes are cellular components of innate immunity and, when triggered, the Toll and Imd pathways signal production of antimicrobial peptides (AMP) as part of humoral defences. We quantified three lines of defence in\n                    <jats:italic>Ae. aegypti<\/jats:italic>\n                    in response to larval nutritional stress, and our data show that important female immune functions are modified by the larval rearing environment. Adult midgut basal lamina thickness was not affected by larval nutrient stress as has been observed in another\n                    <jats:italic>Aedes<\/jats:italic>\n                    sp. However, nutrient stresses experienced by larvae lead to a reduced number of haemocytes in females. Transcripts of Spaetzle (upstream regulator of Toll pathway that leads to induction of AMPs) and some immune\u2010related genes were less abundant in stressed larvae but showed increased expression in females derived from stressed larvae. Results indicate a potential for compensation by the humoral branch for a reduced cellular branch of innate immunity in adults in response to larval nutrient stress.\n                  <\/jats:p>","DOI":"10.1111\/j.1365-2915.2011.00993.x","type":"journal-article","created":{"date-parts":[[2011,11,24]],"date-time":"2011-11-24T00:45:57Z","timestamp":1322095557000},"page":"271-281","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":81,"title":["Larval nutritional stress affects vector immune traits in adult yellow fever mosquito\n                    <i>Aedes aegypti (Stegomyia aegypti)<\/i>"],"prefix":"10.1111","volume":"26","author":[{"given":"A.","family":"TELANG","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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